Prognostic model to predict postoperative acute kidney injury in patients undergoing major gastrointestinal surgery based on a national prospective observational cohort study

STARSurg Collaborative

doi:10.1002/bjs5.86

Prognostic model to predict postoperative acute kidney injury in patients undergoing major gastrointestinal surgery based on a national prospective observational cohort study

BJS Open. 2018 Jul 27;2(6):400-410. doi: 10.1002/bjs5.86. eCollection 2018 Dec.

Author

STARSurg Collaborative

Collaborators

STARSurg Collaborative:
D Nepogodiev, K Walker, J C Glasbey, T M Drake, A Borakati, S Kamarajah, K McLean, C Khatri, N Arulkumaran, E M Harrison, J E Fitzgerald, D Cromwell, J Prowle, A Bhangu, K Walker, T M Drake, D Cromwell, J C Glasbey, A Borakati, T M Drake, S Kamarajah, K McLean, M F Bath, H A Claireaux, B Gundogan, M Mohan, P Deekonda, C Kong, H Joyce, L Mcnamee, E Woin, J Burke, C Khatri, J E Fitzgerald, E M Harrison, A Bhangu, D Nepogodiev, N Arulkumaran, S Bell, F Duthie, J Hughes, T D Pinkney, J Prowle, T Richards, M Thomas, K Dynes, P Patel, C Wigley, R Suresh, A Shaw, S Klimach, P Jull, D Evans, R Preece, I Ibrahim, V Manikavasagar, F S Brown, P Deekonda, R Teo, D P Y Sim, A Borakati, A E Logan, I Barai, H Amin, S Suresh, R Sethi, W Bolton, O Corbridge, L Horne, M Attalla, R Morley, T Hoskins, R McAllister, S Lee, Y Dennis, G Nixon, E Heywood, H Wilson, L Ng, S Samaraweera, A Mill, C Doherty, E Woin, J Belchos, V Phan, T Chouari, T Gardner, N Goergen, J D B Hayes, C S MacLeod, R McCormack, A McKinley, S McKinstry, W Milligan, L Ooi, N M Rafiq, T Sammut, E Sinclair, M Smith, C Baker, A P R Boulton, J Collins, H C Copley, N Fearnhead, H Fox, T Mah, J McKenna, V Naruka, N Nigam, B Nourallah, S Perera, A Qureshi, S Saggar, L Sun, X Wang, D D Yang, P Caroll, C Doyle, S Elangovan, A Falamarzi, K Gascon Perai, E Greenan, D Jain, M Lang-Orsini, S Lim, L O'Byrne, P Ridgway, S Van der Laan, J Wong, J Arthur, J Barclay, P Bradley, C Edwin, E Finch, E Hayashi, M Hopkins, D Kelly, M Kelly, N McCartan, A Ormrod, A Pakenham, J Hayward, C Hitchen, A Kishore, T Martins, J Philomen, R Rao, C Rickards, N Burns, M Copeland, C Durand, A Dyal, A Ghaffar, A Gidwani, M Grant, C Gribbon, A Gruhn, M Leer, K Ahmad, G Beattie, M Beatty, G Campbell, G Donaldson, S Graham, D Holmes, S Kanabar, H Liu, C McCann, R Stewart, S Vara, O Ajibola-Taylor, E J E Andah, C Ani, N M O Cabdi, G Ito, M Jones, A Komoriyama, P Patel, L Titu, M Basra, P Gallogly, G Harinath, S H Leong, A Pradhan, I Siddiqui, S Zaat, A Ali, M Galea, W L Looi, J C K Ng, G Atkin, A Azizi, Z Cargill, Z China, J Elliot, R Jebakumar, J Lam, G Mudalige, C Onyerindu, M Renju, V Shankar Babu, M Hussain, N Joji, B Lovett, H Mownah, B Ali, B Cresswell, A K Dhillon, Y S Dupaguntla, C Hungwe, J D Lowe-Zinola, J C H Tsang, K Bevan, C Cardus, A Duggal, S Hossain, M McHugh, M Scott, F Chan, R Evans, E Gurung, B Haughey, B Jacob-Ramsdale, M Kerr, J Lee, E McCann, K O'Boyle, N Reid, F Hayat, S Hodgson, R Johnston, W Jones, M Khan, T Linn, S Long, P Seetharam, S Shaman, B Smart, A Anilkumar, J Davies, J Griffith, B Hughes, Y Islam, D Kidanu, N Mushaini, I Qamar, H Robinson, M Schramm, C Yan Tan, H Apperley, C Billyard, J M Blazeby, S P Cannon, S Carse, A Göpfert, A Loizidou, J Parkin, E Sanders, S Sharma, G Slade, R Telfer, I Whybrow Huppatz, E Worley, L Chandramoorthy, C Friend, L Harris, P Jain, M J Karim, K Killington, J McGillicuddy, C Rafferty, N Rahunathan, T Rayne, Y Varathan, N Verma, D Zanichelli, M Arneill, F Brown, B Campbell, L Crozier, J Henry, C McCusker, P Prabakaran, R Wilson, U Asif, M Connor, S Dindyal, N Math, A Pagarkar, H Saleem, I Seth, S Sharma, N Standfield, T Swartbol, R Adamson, J E Choi, O El Tokhy, W Ho, N R Javaid, M Kelly, A S Mehdi, D Menon, I Plumptre, S Sturrock, J Turner, O Warren, E Crane, B Ferris, C Gadsby, J Smallwood, M Vipond, V Wilson, T Amarnath, A Doshi, C Gregory, K Kandiah, B Powell, H Spoor, C Toh, R Vizor, M Common, K Dunleavy, S Harris, C Luo, Z Mesbah, A Prem Kumar, A Redmond, S Skulsky, T Walsh, D Daly, L Deery, E Epanomeritakis, M Harty, D Kane, K Khan, R Mackey, J McConville, K McGinnity, G Nixon, A Ang, J Y Kee, E Leung, S Norman, S V Palaniappan, P Partha Sarathy, T Yeoh, J Frost, P Hazeldine, L Jones, M Karbowiak, C Macdonald, A Mutarambirwa, A Omotade, M Runkel, G Ryan, N Sawers, C Searle, S Suresh, S Vig, A Ahmad, R McGartland, R Sim, A Song, J Wayman, R Brown, L H Chang, K Concannon, C Crilly, T J Arnold, A Burgin, F Cadden, C H Choy, M Coleman, D Lim, J Luk, P Mahankali-Rao, A J Prudence-Taylor, D Ramakrishnan, J Russell, A Fawole, J Gohil, B Green, A Hussain, L McMenamin, L McMenamin, M Tang, F Azmi, S Benchetrit, T Cope, A Haque, A Harlinska, R Holdsworth, T Ivo, J Martin, T Nisar, A Patel, K Sasapu, J Trevett, G Vernet, A Aamir, C Bird, A Durham-Hall, W Gibson, J Hartley, N May, V Maynard, S Johnson, C McDonald Wood, M O'Brien, J Orbell, T D Stringfellow, F Tenters, S Tresidder, W Cheung, A Grant, N Tod, M Bews-Hair, Z H Lim, S W Lim, M Vella-Baldacchino, S Auckburally, A Chopada, S Easdon, R Goodson, F McCurdie, M Narouz, A Radford, E Rea, O Taylor, T Yu, M Alfa-Wali, L Amani, I Auluck, P Bruce, J Emberton, R Kumar, N Lagzouli, A Mehta, A Murtaza, M Raja, I S Dennahy, K Frew, A Given, Y Y He, M A Karim, E MacDonald, E McDonald, D McVinnie, S K Ng, A Pettit, D P Y Sim, S D Berthaume-Hawkins, R Charnley, K Fenton, D Jones, C Murphy, J Q Ng, R Reehal, H Robinson, S S Seraj, E Shang, A Tonks, P White, A Yeo, P Chong, R Gabriel, N Patel, E Richardson, L Symons, D Aubrey-Jones, S Dawood, M Dobrzynska, S Faulkner, H Griffiths, F Mahmood, P Patel, M Perry, A Power, R Simpson, A Ali, P Brobbey, A Burrows, P Elder, R Ganyani, C Horseman, P Hurst, H Mann, K Marimuthu, S McBride, E Pilsworth, N Powers, P Stanier, R Innes, T Kersey, M Kopczynska, N Langasco, N Patel, R Rajagopal, B Atkins, W Beasley, Z Cheng Lim, A Gill, H Li Ang, H Williams, T Yogeswara, R Carter, M Fam, J Fong, J Latter, M Long, S Mackinnon, C McKenzie, J Osmanska, V Raghuvir, A Shafi, K Tsang, L Walker, K Bountra, O Coldicutt, D Fletcher, S Hudson, S Iqbal, T Lopez Bernal, J W B Martin, F Moss-Lawton, J Smallwood, M Vipond, A Cardwell, K Edgerton, J Laws, A Rai, K Robinson, K Waite, J Ward, H Youssef, C Knight, P Y Koo, A Lazarou, S Stanger, C Thorn, M C Triniman, A Botha, L Boyles, S Cumming, S Deepak, A Ezzat, A J Fowler, A M Gwozdz, S F Hussain, S Khan, H Li, B Lu Morrell, J Neville, R Nitiahpapand, O Pickering, H Sagoo, E Sharma, K Welsh, S Denley, S Khan, M Agarwal, N Al-Saadi, R Bhambra, A Gupta, Z A R Jawad, L R Jiao, K Khan, G Mahir, S Singagireson, B L Thoms, B Tseu, R Wei, N Yang, N Britton, D Leinhardt, M Mahfooz, A Palkhi, M Price, S Sheikh, M Barker, D Bowley, M Cant, U Datta, M Farooqi, A Lee, G Morley, M Naushad Amin, A Parry, S Patel, S Strang, N Yoganayagam, A Adlan, S Chandramoorthy, Y Choudhary, K Das, M Feldman, B France, R Grace, H Puddy, P Soor, M Ali, P Dhillon, A Faraj, L Gerard, M Glover, H Imran, S Kim, Y Patrick, J Peto, A Prabhudesai, R Smith, A Tang, N Vadgama, R Dhaliwal, T Ecclestone, A Harris, D Ong, D Patel, C Philp, E Stewart, L Wang, E Wong, Y Xu, T Ashaye, T Fozard, F Galloway, S Kaptanis, P Mistry, T Nguyen, F Olagbaiye, M Osman, Z Philip, R Rembacken, S Tayeh, K Theodoropoulou, A Herman, J Lau, A Saha, M Trotter, O Adeleye, D Cave, T Gunwa, J Magalhães, S Makwana, R Mason, M Parish, H Regan, P Renwick, G Roberts, D Salekin, C Sivakumar, A Tariq, I Liew, A McDade, D Stewart, M Hague, N Hudson-Peacock, C E S Jackson, F James, J Pitt, E Y Walker, R Aftab, J J Ang, S Anwar, J Battle, E Budd, J Chui, H Crook, P Davies, S Easby, E Hackney, B Ho, S Z Imam, J Rammell, H Andrews, C Perry, P Schinle, P Ahmed, T Aquilina, E Balai, M Church, E Cumber, A Curtis, G Davies, Y Dennis, E Dumann, S Greenhalgh, P Kim, S King, K H M Metcalfe, L Passby, N Redgrave, Z Soonawalla, S Waters, A Zornoza, I Gulzar, J Hole, K Hull, H Ishaq, J Karaj, A Kelkar, E Love, S Patel, D Thakrar, M Vine, A Waterman, N P Dib, N Francis, M Hanson, R Ingleton, K S Sadanand, N Sukirthan, S Arnell, M Ball, N Bassam, G Beghal, A Chang, V Dawe, A George, T Huq, A Hussain, B Ikram, L Kanapeckaite, M Khan, D Ramjas, A Rushd, S Sait, M Serry, E Yardimci, S Capella, L Chenciner, C Episkopos, E Karam, C McCarthy, W Moore-Kelly, N Watson, V Ahluwalia, J Barnfield, O Ben-Gal, I Bloom, A Gharatya, K Khodatars, N Merchant, A Moonan, M Moore, K Patel, H Spiers, K Sundaram, J Turner, M F Bath, J Black, H Chadwick, L Huisman, H Ingram, S Khan, L Martin, M Metcalfe, P Sangal, J Seehra, A Thatcher, S Venturini, I Whitcroft, Z Afzal, S Brown, A Gani, A Gomaa, N Hussein, S Y Oh, N Pazhaniappan, E Sharkey, T Sivagnanasithiyar, C Williams, J Yeung, L Cruddas, S Gurjar, A Pau, R Prakash, R Randhawa, L Chen, I Eiben, M Naylor, D Osei-Bordom, R Trenear, J Bannard-Smith, N Griffiths, B Y Patel, F Saeed, H Abdikadir, M Bennett, R Church, S E Clements, J Court, A Delvi, J Hubert, B Macdonald, F Mansour, R R Patel, R Perris, S Small, A Betts, N Brown, A Chong, C Croitoru, A Grey, P Hickland, C Ho, D Hollington, L McKie, A R Nelson, H Stewart, P Eiben, M Nedham, I Ali, T Brown, S Cumming, C Hunt, C Joyner, C McAlinden, J Roberts, D Rogers, A Thachettu, N Tyson, R Vaughan, N Verma, T Yasin, K Andrew, N Bhamra, S Leong, R Mistry, H Noble, F Rashed, N R Walker, L Watson, M Worsfold, E Yarham, H Abdikadir, A Arshad, B Barmayehvar, L Cato, N Chan-Lam, V Do, A Leong, Z Sheikh, T Zheleniakova, J Coppel, S T Hussain, R Mahmood, R Nourzaie, J Prowle, S Sheik-Ali, A Thomas, A Alagappan, R Ashour, H Bains, J Diamond, J Gordon, B Ibrahim, M Khalil, D Mittapalli, Y N Neo, P Patil, F S Peck, N Reza, I Swan, M Whyte, S Chaudhry, J Hernon, H Khawar, J O'Brien, M Pullinger, K Rothnie, S Ujjal, S Bhatte, J Curtis, S Green, A Mayer, G Watkinson, K Chapple, T Hawthorne, M Khaliq, L Majkowski, T A M Malik, K Mclauchlan, B Ng Wei En, T O'Connor, S Parton, S D Robinson, M I Saat, B N Shurovi, K Varatharasasingam, A E Ward, K Behranwala, M Bertelli, J Cohen, F Duff, O Fafemi, R Gupta, M Manimaran, J Mayhew, D Peprah, M H Y Wong, N Farmer, C Houghton, N Kandhari, K Khan, D Ladha, J Mayes, F McLennan, P Panahi, H Seehra, R Agrawal, I Ahmed, S Ali, F Birkinshaw, M Choudhry, S Gokani, S Harrogate, S Jamal, F Nawrozzadeh, A Swaray, A Szczap, J Warusavitarne, M Abdalla, N Asemota, R Cullum, M Hartley, C Maxwell-Armstrong, C Mulvenna, J Phillips, A Yule, L Ahmed, K D Clement, N Craig, E Elseedawy, D Gorman, L Kane, J Livie, V Livie, E Moss, A Naasan, F Ravi, P Shields, Y Zhu, M Archer, H Cobley, R Dennis, C Downes, B Guevel, E Lamptey, H Murray, A Radhakrishnan, S Saravanabavan, M Sardar, C Shaw, V Tilliridou, R Wright, W Ye, N Alturki, R Helliwell, E Jones, D Kelly, S Lambotharan, K Scott, R Sivakumar, L Victor, H Boraluwe-Rallage, P Froggatt, S Haynes, Y M A Hung, A Keyte, L Matthews, E Evans, P Haray, I John, A Mathivanan, L Morgan, O Oji, C Okorocha, A Rutherford, H Spiers, N Stageman, A Tsui, R Whitham, A Amoah-Arko, E Cecil, A Dietrich, H Fitzpatrick, C Guy, J Hair, J Hilton, L Jawad, E McAleer, Z Taylor, J Yap, M Akhbari, D Debnath, T Dhir, M Elbuzidi, M Elsaddig, S Glace, H Khawaja, R Koshy, K Lal, L Lobo, A McDermott, J Meredith, M A Qamar, A Vaidya, F Acquaah, L Barfi, N Carter, D Gnanappiragasam, C Ji, F Kaminski, S Lawday, K Mackay, S K Sulaiman, R Webb, P Ananthavarathan, F Dalal, E Farrar, R Hashemi, M Hossain, J Jiang, M Kiandee, J Lex, L Mason, J H Matthews, E McGeorge, S Modhwadia, T Pinkney, A Radotra, L Rickard, L Rodman, A Sales, K L Tan, A Bachi, D S Bajwa, J Battle, L R Brown, A Butler, A Calciu, E Davies, I Gardner, T Girdlestone, O Ikogho, G Keelan, P O'Loughlin, J Tam, J Elias, M Ngaage, J Thompson, S Bristow, E Brock, H Davis, M Pantelidou, A Sathiyakeerthy, K Singh, A Chaudhry, G Dickson, P Glen, K Gregoriou, H Hamid, A Mclean, P Mehtaji, G Neophytou, S Potts, D R Belgaid, J Burke, J Durno, N Ghailan, M Hanson, V Henshaw, U R Nazir, I Omar, B J Riley, J Roberts, G Smart, K Van Winsen, A Bhatti, M Chan, M D'Auria, S Green, C Keshvala, H Li, C Maxwell-Armstrong, M Michaelidou, L Simmonds, C Smith, A Wimalathasan, J Abbas, C Cairns, Y R Chin, A Connelly, S Moug, A Nair, D Svolkinas, P Coe, D Subar, H Wang, V Zaver, J Brayley, P Cookson, L Cunningham, A Gaukroger, M Ho, A Hough, J King, D O'Hagan, A Widdison, B Brown, R Brown, A Chavan, S Francis, L Hare, J Lund, N Malone, B Mavi, A McIlwaine, S Rangarajan, N Abuhussein, H S Campbell, J Daniels, I Fitzgerald, S Mansfield, A Pendrill, D Robertson, Y W Smart, T Teng, J Yates, A Belgaumkar, A Katira, J Kossoff, S Kukran, C Laing, B Mathew, T Mohamed, S Myers, R Novell, B L Phillips, M Thomas, T Turlejski, S Turner, M Varcada, L Warren, W Wynell-Mayow, R Church, L Linley-Adams, G Osborn, M Saunders, R Spencer, M Srikanthan, S Tailor, A Tullett, M Ali, S Al-Masri, G Carr, O Ebhogiaye, S Heng, S Manivannan, J Manley, L E McMillan, C Peat, B Phillips, S Thomas, H Whewell, G Williams, A Bienias, E A Cope, G R Courquin, L Day, C Garner, A Gimson, C Harris, K Markham, T Moore, T Nadin, C Phillips, S M Subratty, K Brown, J Dada, M Durbacz, T Filipescu, E Harrison, E D Kennedy, E Khoo, D Kremel, I Lyell, S Pronin, R Tummon, C Ventre, L Walls, E Wootton, A Akhtar, E Davies, D El-Sawy, M Farooq, M Gaddah, H Griffiths, I Katsaiti, N Khadem, K Leong, I Williams, C S Chean, D Chudek, H Desai, N Ellerby, A Hammad, S Malla, B Murphy, O Oshin, P Popova, S Rana, T Ward, T E F Abbott, O Akpenyi, F Edozie, R El Matary, W English, S Jeyabaladevan, C Morgan, V Naidu, K Nicholls, S Peroos, J Prowle, S Sansome, H D Torrance, D Townsend, J Brecher, H Fung, Z Kazmi, P Outlaw, K Pursnani, N Ramanujam, A Razaq, M Sattar, S Sukumar, T S E Tan, K Chohan, S Dhuna, T Haq, S Kirby, J Lacy-Colson, P Logan, Q Malik, J McCann, Z Mughal, S Sadiq, I Sharif, C Shingles, A Simon, S Burnage, S S N Chan, A R J Craig, J Duffield, A Dutta, M Eastwood, F Iqbal, F Mahmood, W Mahmood, C Patel, A Qadeer, A Robinson, A Rotundo, A Schade, R D Slade, M De Freitas, H Kinnersley, E McDowell, S Moens-Lecumberri, J Ramsden, T Rockall, L Wiffen, S Wright, C Bruce, V Francois, K Hamdan, C Limb, A J Lunt, L Manley, M Marks, C F E Phillips, C J F Agnew, C J Barr, N Benons, S J Hart, D Kandage, R Krysztopik, P Mahalingam, J Mock, S Rajendran, M T Stoddart, B Clements, H Gillespie, S Lee, R McDougall, C Murray, R O'Loane, S Periketi, S Tan, R Amoah, R Bhudia, B Dudley, A Gilbert, B Griffiths, H Khan, N McKigney, B Roberts, R Samuel, A Seelarbokus, A Stubbing-Moore, G Thompson, P Williams, N Ahmed, R Akhtar, E Chandler, I Chappelow, H Gil, T Gower, A Kale, G Lingam, L Rutler, C Sellahewa, A Sheikh, H Stringer, R Taylor, H Aglan, M R Ashraf, S Choo, E Das, J Epstein, R Gentry, D Mills, Y Poolovadoo, N Ward, K Bull, A Cole, J Hack, S Khawari, C Lake, T Mandishona, R Perry, S Sleight, S Sultan, T Thornton, S Williams, T Arif, A Castle, P Chauhan, R Chesner, T Eilon, S Kamarajah, C Kambasha, L Lock, T Loka, F Mohammad, S Motahariasl, L Roper, S S Sadhra, A Sheikh, T Toma, Q Wadood, J Yip, E Ainger, S Busti, L Cunliffe, T Flamini, S Gaffing, C Moorcroft, M Peter, L Simpson, E Stokes, G Stott, J Wilson, J York, A Yousaf, A Borakati, M Brown, A Goaman, B Hodgson, A Ijeomah, U Iroegbu, G Kaur, C Lowe, S Mahmood, Z Sattar, P Sen, A Szuman, N Abbas, M Al-Ausi, N Anto, R Bhome, L Eccles, J Elliott, E J Hughes, A Jones, A S Karunatilleke, J S Knight, C C F Manson, I Mekhail, L Michaels, T M Noton, E Okenyi, T Reeves, I H Yasin, D A Banfield, R Harris, D Lim, C Mason-Apps, T Roe, J Sandhu, N Shafiq, E Stickler, J P Tam, L M Williams, P Ainsworth, Y Boualbanat, C Doull, E Egan, L Evans, K Hassanin, G Ninkovic-Hall, W Odunlami, M Shergill, M Traish, D Cummings, S Kershaw, J Ong, F Reid, H Toellner, A Alwandi, M Amer, D George, K Haynes, K Hughes, L Peakall, Y Premakumar, N Punjabi, A Ramwell, H Sawkins, J Ashwood, A Baker, C Baron, I Bhide, E Blake, C De Cates, R Esmail, H Hosamuddin, J Kapp, N Nguru, M Raja, F Thomson, H Ahmed, G Aishwarya, R Al-Huneidi, S Ali, R Aziz, D Burke, B Clarke, A Kausar, D Maskill, L Mecia, L Myers, A C D Smith, G Walker, N Wroe, C Donohoe, D Gibbons, P Jordan, C Keogh, A Kiely, P Lalor, M McCrohan, C Powell, M Power Foley, J Reynolds, E Silke, O Thorpe, J Tseun Han Kong, C White, Q Ali, J Dalrymple, Y Ge, H Khan, R S Luo, H Paine, B Paraskeva, L Parker, K Pillai, J Salciccioli, S Selvadurai, V Sonagara, L R Springford, L Tan, S Appleton, N Leadholm, Y Zhang, D Ahern, M Cotter, S Cremen, T Durrigan, V Flack, N Hrvacic, H Jones, B Jong, K Keane, P R O'Connell, J O'Sullivan, G Pek, S Shirazi, C Barker, A Brown, W Carr, Y Chen, C Guillotte, J Harte, A Kokayi, K Lau, S McFarlane, S Morrison, J Broad, N Kenefick, D Makanji, V Printz, R Saito, O Thomas, H Breen, S Kirk, C H Kong, A O'Kane, M Eddama, A Engledow, S K Freeman, A Frost, C Goh, G Lee, R Poonawala, A Suri, P Taribagil, H Brown, S Christie, S Dean, R Gravell, E Haywood, F Holt, E Pilsworth, R Rabiu, H W Roscoe, S Shergill, A Sriram, A Sureshkumar, L C Tan, A Tanna, A Vakharia, S Bhullar, S Brannick, E Dunne, M Frere, M Kerin, K Muthu Kumar, T Pratumsuwan, R Quek, M Salman, N Van Den Berg, C Wong, J Ahluwalia, R Bagga, C M Borg, C Calabria, A Draper, M Farwana, H Joyce, A Khan, M Mazza, G Pankin, M S Sait, N Sandhu, N Virani, J Wong, K Woodhams, N Croghan, S Ghag, G Hogg, O Ismail, N John, K Nadeem, M Naqi, S M Noe, A Sharma, S Tan, F Begum, R Best, A Collishaw, J Glasbey, D Golding, B Gwilym, P Harrison, T Jackman, N Lewis, Y L Luk, T Porter, S Potluri, M Stechman, S Tate, D Thomas, B Walford, F Auld, A Bleakley, S Johnston, C Jones, J Khaw, S Milne, S O'Neill, K K R Singh, R Smith, A Swan, N Thorley, S Yalamarthi, Z D Yin, A Ali, V Balian, R Bana, K Clark, C Livesey, G McLachlan, M Mohammad, N Pranesh, C Richards, F Ross, M Sajid, M Brooke, J Francombe, J Gresly, S Hutchinson, K Kerrigan, E Matthews, S Nur, L Parsons, A Sandhu, M Vyas, F White, A Zulkifli, L Zuzarte, A Al-Mousawi, J Arya, S Azam, A Azri Yahaya, K Gill, R Hallan, C Hathaway, I Leptidis, L McDonagh, S Mitrasinovic, N Mushtaq, N Pang, G B Peiris, S Rinkoff, L Chan, E Christopher, M M H Farhan-Alanie, A Gonzalez-Ciscar, C J Graham, H Lim, K A McLean, H M Paterson, A Rogers, C Roy, D Rutherford, F Smith, G Zubikarai, R Al-Khudairi, M Bamford, M Chang, J Cheng, C Hedley, R Joseph, B Mitchell, S Perera, L Rothwell, A Siddiqui, J Smith, K Taylor, O Wroe Wright, H K Baryan, G Boyd, H Conchie, L Cox, J Davies, S Gardner, N Hill, K Krishna, F Lakin, S Scotcher, J Alberts, M Asad, J Barraclough, A Campbell, D Marshall, W Wakeford, P Cronbach, F D'Souza, E Gammeri, J Houlton, M Hall, A Kethees, R Patel, M Perera, J Prowle, M Shaid, E Webb, S Beattie, M Chadwick, O El-Taji, S Haddad, M Mann, M Patel, K Popat, L Rimmer, H Riyat, H Smith, C Anandarajah, M Cipparrone, K Desai, C Gao, E T Goh, M Howlader, N Jeffreys, A Karmarkar, G Mathew, H Mukhtar, E Ozcan, A Renukanthan, N Sarens, C Sinha, A Woolley, R Bogle, O Komolafe, F Loo, D Waugh, R Zeng, A Crewe, J Mathias, A Mills, A Owen, A Prior, I Saunders, A Baker, L Crilly, J McKeon, H K Ubhi, A Adeogun, R Carr, C Davison, S Devalia, A Hayat, R B Karsan, C Osborne, K Scott, C Weegenaar, M Wijeyaratne, F Babatunde, E Barnor-Ahiaku, G Beattie, P Chitsabesan, O Dixon, N Hall, N Ilenkovan, T Mackrell, N Nithianandasivam, J Orr, F Palazzo, M Saad, L Sandland-Taylor, J Sherlock, T Ashdown, S Chandler, T Garsaa, J Lloyd, S Y Loh, S Ng, C Perkins, A Powell-Chandler, F Smith, R Underhill

PMID: 30513129
PMCID: PMC6254006
DOI: 10.1002/bjs5.86

Abstract

Background: Acute illness, existing co-morbidities and surgical stress response can all contribute to postoperative acute kidney injury (AKI) in patients undergoing major gastrointestinal surgery. The aim of this study was prospectively to develop a pragmatic prognostic model to stratify patients according to risk of developing AKI after major gastrointestinal surgery.

Methods: This prospective multicentre cohort study included consecutive adults undergoing elective or emergency gastrointestinal resection, liver resection or stoma reversal in 2-week blocks over a continuous 3-month period. The primary outcome was the rate of AKI within 7 days of surgery. Bootstrap stability was used to select clinically plausible risk factors into the model. Internal model validation was carried out by bootstrap validation.

Results: A total of 4544 patients were included across 173 centres in the UK and Ireland. The overall rate of AKI was 14·2 per cent (646 of 4544) and the 30-day mortality rate was 1·8 per cent (84 of 4544). Stage 1 AKI was significantly associated with 30-day mortality (unadjusted odds ratio 7·61, 95 per cent c.i. 4·49 to 12·90; P < 0·001), with increasing odds of death with each AKI stage. Six variables were selected for inclusion in the prognostic model: age, sex, ASA grade, preoperative estimated glomerular filtration rate, planned open surgery and preoperative use of either an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker. Internal validation demonstrated good model discrimination (c-statistic 0·65).

Discussion: Following major gastrointestinal surgery, AKI occurred in one in seven patients. This preoperative prognostic model identified patients at high risk of postoperative AKI. Validation in an independent data set is required to ensure generalizability.

Abstract

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