Objective: To analyze the clinical features and prognosis of cervical adenocarcinoma (AC) and adenosquamous carcinoma of cervix (ASC).
Methods: The clinical data of 237 patients, including 201 cases of AC and 36 cases of ASC (FIGO stage ⅠB1-ⅡA), who underwent surgery in Qilu Hospital between September 2007 and September 2016 were reviewed. Clinical features of two groups were compared, and Kaplan-Meier survival analysis was performed to evaluate the prognosis.
Results: A larger proportion of ASC patients had lymphovascular space invasion compared with AC patients (P<0.01), but no significant differences were observed in the age, FIGO stage, size of tumor, depth of stromal invasion, parametrial invasion, lymphatic metastasis and risk grade between two groups (all P>0.05). The 5-year overall survival rates of AC and ASC groups were 79.4% and 78.3%, and the 5-year recurrence-free survival rates were 77.4% and 73.0%. Among patients received concurrent chemoradiotherapy, the 5-year overall survival rates were 71.0% and 61.4%, and the 5-year recurrence-free survival rates were 68.8% abd 61.1%, respectively. No significant differences were observed in 5-year overall survival rates and recurrence-free survival rates between AC and ASC patients (all P>0.05).
Conclusions: Lymphovascular space invasion was more likely to occur in patients with ASC, but there was no significant difference in the prognosis between AC and ASC patients.
目的: 探讨宫颈腺癌和宫颈腺鳞癌患者的临床特征和预后差异。
方法: 回顾性分析2007年9月至2016年9月因ⅠB1~ⅡA期宫颈腺癌（201例）或宫颈腺鳞癌（36例）在山东大学齐鲁医院手术治疗患者的临床资料。比较两组的临床特征，并采用Kaplan-Meier生存曲线对两种组织学类型宫颈癌的预后进行评价。
结果: 宫颈腺鳞癌组淋巴血管浸润比例较宫颈腺癌组高（ P < 0.01），而在年龄、FIGO分期、肿瘤直径、间质浸润深度、宫旁浸润、淋巴结转移和危险分级方面两组差异均无统计学意义（均 P>0.05）。宫颈腺癌组和宫颈腺鳞癌组患者5年总存活率分别为79.4%和78.3%，5年无复发存活率分别为77.4%和73.0%，组间差异均无统计学意义（均 P>0.05）。术后接受同步放射治疗和化疗的患者中，5年总存活率分别为71.0%和61.4%，5年无复发存活率分别为68.8%和61.1%，组间差异均无统计学意义（均 P>0.05）。
结论: 宫颈腺鳞癌较宫颈腺癌更易发生淋巴血管浸润，但两者的预后相似。