Data characterizing the biophysical and nitric oxide release properties of the tDodSNO - Styrene maleic anhydride nanoparticle SMA-tDodSNO

Houman Alimoradi; Anita Barzegar-Fallah; Ivan A Sammut; Khaled Greish; Gregory I Giles

doi:10.1016/j.dib.2018.10.149

Data characterizing the biophysical and nitric oxide release properties of the tDodSNO - Styrene maleic anhydride nanoparticle SMA-tDodSNO

Data Brief. 2018 Nov 3:21:1771-1775. doi: 10.1016/j.dib.2018.10.149. eCollection 2018 Dec.

Authors

Houman Alimoradi¹, Anita Barzegar-Fallah¹, Ivan A Sammut¹, Khaled Greish², Gregory I Giles¹

Affiliations

¹ Department of Pharmacology and Toxicology, University of Otago, Dunedin, New Zealand.
² College of Medicine and Medical Sciences, Department of Molecular Medicine and Nanomedicine Unit, Princess Al-Jawhara Center for Molecular Medicine and Inherited Disorders, Arabian Gulf University, Manama, Bahrain.

Abstract

Nitric oxide (NO) donor drugs have a range of clinical applications, and are also being developed as therapeutics for the potential treatment of multiple diseases. This article presents data describing the synthesis and characterisation of a novel NO releasing nanoparticle formed by encapsulation of the NO donor tDodSNO into a co-polymer of styrene and maleic acid (SMA) to afford SMA-tDodSNO. The pharmacological activity of SMA-tDodSNO is discussed in our accompanying manuscript "Encapsulation of tDodSNO generates a photoactivated nitric oxide releasing nanoparticle for localized control of vasodilation and vascular hyperpermeability". (Alimoradio et al. [1]).