Occult mucin-producing urothelial-type adenocarcinoma of the prostate with elevated serum levels of carcinoembryonic antigen and carbohydrate antigen 19-9: Report of an autopsy-proven case

Keisuke Nonaka; Yoko Matsuda; Mototsune Kakizaki; Shoichiro Takakuma; Tomoyasu Matsubara; Shigeo Murayama; Toshiyuki Ishiwata; Masashi Kameyama; Kazuto Ogura; Sumiko Kobayashi; Tomio Arai

doi:10.1016/j.eucr.2018.11.005

Occult mucin-producing urothelial-type adenocarcinoma of the prostate with elevated serum levels of carcinoembryonic antigen and carbohydrate antigen 19-9: Report of an autopsy-proven case

Urol Case Rep. 2018 Nov 15:23:6-9. doi: 10.1016/j.eucr.2018.11.005. eCollection 2019 Mar.

Affiliations

¹ Department of Pathology, Tokyo Metropolitan Geriatric Hospital, 35-2 Sakae-cho, Itabashi-ku, Tokyo, 173-0015, Japan.
² Department of Neuropathology (Brain Bank for Aging Research), Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo, 173-0015, Japan.
³ Division of Aging and Carcinogenesis, Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo, 173-0015, Japan.
⁴ Department of Radiology, Tokyo Metropolitan Geriatric Hospital, 35-2 Sakae-cho, Itabashi-ku, Tokyo, 173-0015, Japan.
⁵ Department of Hematology, Tokyo Metropolitan Geriatric Hospital, 35-2 Sakae-cho, Itabashi-ku, Tokyo, 173-0015, Japan.

Abstract

Mucin-producing urothelial-type adenocarcinoma of the prostate (MPUAP) is a rare, aggressive neoplasm thought to originate from the prostatic urethral urothelium. Our case is the first reported to show significantly increased serum levels of carcinoembryonic antigen (CEA) and carbohydrate antigen (CA) 19-9 in MPUAP. An autopsy revealed occult MPUAP with prominent seminal vesicle, perineural, lymphatic vessel, and vascular invasion and extensive bone metastases. Duration of survival in this case was far shorter than average, and extensive bone metastases were rare in previously reported cases. This suggests serum CEA and CA19-9 levels can be an important prognostic factor in MPUAP.

Keywords: 18F-FDG-PET, fluorine-18 fluorodeoxyglucose positron emission tomography; CA19-9, carbohydrate antigen 19-9; CDX2, caudal-related homeobox 2; CEA, carcinoembryonic antigen; CK, cytokeratin; Carbohydrate antigen 19-9; Carcinoembryonic antigen; Mucin-producing urothelial-type adenocarcinoma of prostate; PSA, prostate-specific antigen; Prostate-specific antigen.

Publication types

Case Reports