Three new diterpenoid alkaloids isolated from Aconitum brevicalcaratum

Yan Shu; Tian-Peng Yin; Jia-Peng Wang; Dong Gan; Qin-Yan Zhang; Le Cai; Zhong-Tao Ding

doi:10.1016/S1875-5364(18)30128-6

Three new diterpenoid alkaloids isolated from Aconitum brevicalcaratum

Chin J Nat Med. 2018 Nov;16(11):866-870. doi: 10.1016/S1875-5364(18)30128-6.

Authors

Yan Shu¹, Tian-Peng Yin², Jia-Peng Wang¹, Dong Gan¹, Qin-Yan Zhang¹, Le Cai³, Zhong-Tao Ding⁴

Affiliations

¹ Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China.
² Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China; Zhuhai Key Laboratory of Fundamental and Applied Research in Traditional Chinese Medicine, Zunyi Medical University Zhuhai Campus, Zhuhai 519041, China.
³ Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China. Electronic address: caile@ynu.edu.cn.
⁴ Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China. Electronic address: ztding@ynu.edu.cn.

PMID: 30502768
DOI: 10.1016/S1875-5364(18)30128-6

Abstract

In the present study, three new aconitine-type diterpenoid alkaloids brochyponines A-C (1-3) were isolated from the roots of Aconitum brevicalcaratum. Their structures were established on the basis of extensive spectroscopic analyses (IR, HR-ESI-MS, and 1D and 2D NMR). The NMR data of salt form for compound 1 in CDCl₃ were also measured.

Keywords: Aconitum brevicalcaratum; Brochyponine; Diterpenoid alkaloid; Ranunculaceae.

MeSH terms

Aconitum / chemistry*
Alkaloids / chemistry*
Alkaloids / isolation & purification
Drugs, Chinese Herbal / chemistry*
Drugs, Chinese Herbal / isolation & purification
Magnetic Resonance Spectroscopy
Molecular Structure
Plant Roots / chemistry

Substances

Alkaloids
Drugs, Chinese Herbal