Nanoyttria attenuates isoproterenol-induced cardiac injury

Nanomedicine (Lond). 2018 Dec;13(23):2961-2980. doi: 10.2217/nnm-2018-0223. Epub 2018 Dec 3.

Abstract

Aim: The present study was designed to probe the cardioprotective effects of nanoyttria (NY).

Materials & methods: NY was characterized using various techniques. Isoproterenol (ISO)-induced cardiotoxicity challenged mice were treated with NY for 28 days at two doses (0.4 and 4 mg/kg, intraperitoneally).

Results: NY demonstrated free radical scavenging activity as shown by a 2,2-diphenyl-1-picrylhydrazyl assay. NY treatment showed alleviation of ISO-induced cardiotoxicity as evident from the reduction in biochemical parameters. The expression of proinflammatory cytokines (IL-1β, IL-6 and TNF-α) showed significant decrease upon NY treatment. Histopathology and ECG showed protection in histoarchitecture and rhythm of heart, respectively. Reduction in hydroxyproline and TGF-β1 expression indicated antifibrotic activity.

Conclusion: We report for the first time that NY ameliorates ISO-induced cardiac remodeling.

Keywords: cardiac remodeling; fibrosis; inflammation; nanoyttria; oxidative stress.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cardiotoxicity / drug therapy
  • Cytokines / metabolism
  • Gene Expression Regulation / drug effects
  • Heart
  • Heart Injuries / chemically induced
  • Heart Injuries / drug therapy*
  • Hydroxyproline / metabolism
  • Isoproterenol / toxicity
  • Male
  • Mice
  • Myocardial Infarction / drug therapy
  • Nanoparticles / metabolism*
  • Oxidative Stress / drug effects
  • Particle Size
  • RAW 264.7 Cells
  • Surface Properties
  • Yttrium / chemistry*

Substances

  • Cytokines
  • Yttrium
  • Isoproterenol
  • Hydroxyproline
  • yttria