Hepatosplenic T-Cell Lymphoma in an Immunocompetent Male with Central Nervous System Invasion: A Rare Clinical Entity

Cytometry B Clin Cytom. 2019 Nov;96(6):475-479. doi: 10.1002/cyto.b.21736. Epub 2018 Nov 30.

Abstract

Hepatosplenic T-cell lymphoma (HSTCL) is a very rare non-Hodgkin lymphoma with an aggressive clinical course and poor prognosis. Patients of this disease usually presented with hepatosplenomegaly, which can be misdiagnosed or delayed. Bone marrow (BM) and peripheral blood (PB) are frequently involved, however, central nervous system (CNS) involvement is less common. Here, we are reporting an unusual case of hepatosplenic γδ T-cell lymphoma in a 64-year-old man with CNS involvement. Flow cytometry immunophenotyping was proved of great diagnostic contribution. © 2018 International Clinical Cytometry Society.

Keywords: flow cytometry; hepatosplenic T-cell lymphoma; hepatosplenomegaly; immunophenotyping.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Central Nervous System Neoplasms / diagnosis*
  • Central Nervous System Neoplasms / immunology
  • Central Nervous System Neoplasms / secondary*
  • Flow Cytometry*
  • Humans
  • Liver Neoplasms / diagnosis*
  • Liver Neoplasms / immunology
  • Lymphoma, T-Cell / diagnosis*
  • Lymphoma, T-Cell / immunology
  • Male
  • Middle Aged
  • Optical Imaging
  • Splenic Neoplasms / diagnosis*
  • Splenic Neoplasms / immunology