Phosphatidic Acid Enters into the YAP/TAZ Arena

Antonio Totaro; Stefano Piccolo

doi:10.1016/j.molmed.2018.11.002

Phosphatidic Acid Enters into the YAP/TAZ Arena

Trends Mol Med. 2019 Jan;25(1):5-7. doi: 10.1016/j.molmed.2018.11.002. Epub 2018 Nov 26.

Authors

Antonio Totaro¹, Stefano Piccolo²

Affiliations

¹ Department of Molecular Medicine, University of Padua, Padua, Italy.
² Department of Molecular Medicine, University of Padua, Padua, Italy; IFOM, The FIRC Institute of Molecular Oncology, Padua, Italy. Electronic address: piccolo@bio.unipd.it.

PMID: 30497943
DOI: 10.1016/j.molmed.2018.11.002

Abstract

Reporting in Molecular Cell, Han et al. (2018;2:328-340) show that phosphatidic acid promotes YAP activity through a double-hit inhibition of the LATS kinases, suggesting a therapeutic opportunity for the treatment of YAP/TAZ-dependent cancers and opening new prospects on the connections between lipid signaling and YAP/TAZ biology.

Keywords: LATS; YAP; lipid signaling; phosphatidic acid.

MeSH terms

Adaptor Proteins, Signal Transducing / genetics
Adaptor Proteins, Signal Transducing / metabolism*
Animals
Humans
Intracellular Signaling Peptides and Proteins / genetics
Intracellular Signaling Peptides and Proteins / metabolism*
Phosphatidic Acids / therapeutic use*
Signal Transduction / drug effects
Transcription Factors / metabolism*

Substances

Adaptor Proteins, Signal Transducing
Intracellular Signaling Peptides and Proteins
Phosphatidic Acids
Transcription Factors