The N-terminal 14-mer model peptide of human Ctr1 can collect Cu(ii) from albumin. Implications for copper uptake by Ctr1

Metallomics. 2018 Dec 12;10(12):1723-1727. doi: 10.1039/c8mt00274f.

Abstract

Human cells acquire copper primarily via the copper transporter 1 protein, hCtr1. We demonstrate that at extracellular pH 7.4 CuII is bound to the model peptide hCtr11-14via an ATCUN motif and such complexes are strong enough to collect CuII from albumin, supporting the potential physiological role of CuII binding to hCtr1.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Binding Sites
  • Biological Transport
  • Cation Transport Proteins / chemistry
  • Cation Transport Proteins / metabolism*
  • Copper / chemistry
  • Copper / metabolism*
  • Copper Transporter 1
  • Humans
  • Models, Molecular
  • Peptide Fragments / metabolism*
  • Protein Binding
  • Serum Albumin, Human / chemistry
  • Serum Albumin, Human / metabolism*

Substances

  • Cation Transport Proteins
  • Copper Transporter 1
  • Peptide Fragments
  • SLC31A1 protein, human
  • Copper
  • Serum Albumin, Human