Oligopeptide derived from solid-state fermented cottonseed meal significantly affect the immunomodulatory in BALB/c mice treated with cyclophosphamide

Jiancheng Liu; Hong Sun; Cunxi Nie; Wenxia Ge; Yongqiang Wang; Wenju Zhang

doi:10.1007/s10068-018-0414-1

Oligopeptide derived from solid-state fermented cottonseed meal significantly affect the immunomodulatory in BALB/c mice treated with cyclophosphamide

Food Sci Biotechnol. 2018 Jun 20;27(6):1791-1799. doi: 10.1007/s10068-018-0414-1. eCollection 2018 Dec.

Authors

Jiancheng Liu¹, Hong Sun², Cunxi Nie¹, Wenxia Ge¹, Yongqiang Wang¹, Wenju Zhang¹

Affiliations

¹ 1College of Animal Science and Technology, Shihezi University, North Street 4, 832000 Shihezi, China.
² Institute of Plant Protection and Microbiology, Zhejiang Academy of Agriculture Sciences, Hangzhou, China.

Abstract

In this study, the immunomodulatory activity of oligopeptide (CP) derived from solid-state fermented cottonseed meal were investigated in immunosuppressed BALB/c mice models by treatment with cyclophosphamide (CY). Results indicated that oligopeptide increased the thymus and spleen indices of CY-treated mice. The count of plague forming cells (PFC) and the content of half serum hemolysis (HC₅₀) in immunosuppressive mice were restored to the normal level in CP-10 and CP-20 groups while the cytokines interleukin (IL)-2, IL-6, and tumor necrosis factor alpha (TNF-α) were increased significantly in CP-20 group. Similar increasing the immunoglobulin of IgG and IgM content in the serum of CP-10 group were also observed. These findings indicated that oligopeptide derived from solid-state fermented cottonseed meal had a strong immune-enhancing activity as well as a protective effect against immunosuppression induced by cyclophosphamide in mice.

Keywords: Cottonseed meal; Cyclophosphamide; Immunomodulatory; Oligopeptide; Solid-state fermentation.