Thinking through acidic Ca2+ stores

Sci Signal. 2018 Nov 27;11(558):eaau3342. doi: 10.1126/scisignal.aau3342.

Abstract

Glutamate signaling regulates neuronal activity and synaptic plasticity, which underlies learning and memory. In this issue of Science Signaling, Foster et al found that metabotropic glutamate receptors mediate long-term potentiation in hippocampal neurons by mobilizing acidic endolysosomal Ca2+ stores through the intracellular messenger NAADP.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review
  • Comment

MeSH terms

  • Calcium
  • Calcium Signaling
  • Hippocampus
  • Long-Term Potentiation*
  • NADP / analogs & derivatives
  • Receptors, Metabotropic Glutamate*

Substances

  • Receptors, Metabotropic Glutamate
  • metabotropic glutamate receptor type 1
  • NADP
  • NAADP
  • Calcium