Hypothesis: Presymptomatic treatment of Sturge-Weber Syndrome With Aspirin and Antiepileptic Drugs May Delay Seizure Onset

Alyssa M Day; Adrienne M Hammill; Csaba Juhász; Anna L Pinto; E Steve Roach; Charles E McCulloch; Anne M Comi; National Institutes of Health Sponsor: Rare Diseases Clinical Research Network (RDCRN) Brain and Vascular Malformation Consortium (BVMC) SWS Investigator Group

doi:10.1016/j.pediatrneurol.2018.04.009

Hypothesis: Presymptomatic treatment of Sturge-Weber Syndrome With Aspirin and Antiepileptic Drugs May Delay Seizure Onset

Pediatr Neurol. 2019 Jan:90:8-12. doi: 10.1016/j.pediatrneurol.2018.04.009. Epub 2018 Nov 24.

Authors

Alyssa M Day¹, Adrienne M Hammill², Csaba Juhász³, Anna L Pinto⁴, E Steve Roach⁵, Charles E McCulloch⁶, Anne M Comi⁷; National Institutes of Health Sponsor: Rare Diseases Clinical Research Network (RDCRN) Brain and Vascular Malformation Consortium (BVMC) SWS Investigator Group

Collaborators

National Institutes of Health Sponsor: Rare Diseases Clinical Research Network (RDCRN) Brain and Vascular Malformation Consortium (BVMC) SWS Investigator Group:
Karen L Ball⁸, Brian J Fisher⁸, Jim I Koenig⁹, Michael T Lawton¹⁰, Warren D Lo¹¹, Douglas A Marchuk¹², Daniel K Miles¹³, Marsha A Moses¹⁴, Angus A Wilfong¹⁵

Affiliations

¹ Department of Neurology, Hugo Moser Kennedy Krieger Research Institute, Baltimore, Maryland.
² Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio.
³ Departments of Pediatrics, Neurology and Neurosurgery, Wayne State University School of Medicine, Children's Hospital of Michigan, Detroit, Michigan.
⁴ Department of Neurology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
⁵ Division of Child Neurology, Nationwide Children's Hospital, Ohio State University, Columbus, Ohio.
⁶ Department of Epidemiology and Biostatistics, University of California, San Francisco, California.
⁷ Department of Neurology, Hugo Moser Kennedy Krieger Research Institute, Baltimore, Maryland; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland; Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland. Electronic address: comi@kennedykrieger.org.
⁸ The Sturge-Weber Foundation, Houston, TX.
⁹ National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD.
¹⁰ Department of Neurosurgery, Barrow Neurological Institute, Phoenix Children's Hospital, Phoenix, AZ.
¹¹ Department of Neurology, Nationwide Children's Hospital, Columbus, OH.
¹² Molecular Genetics and Microbiology Department, Duke University School of Medicine, Durham, NC.
¹³ Department of Neurology, Pediatric Epilepsy, New York University Langone Health, New York, NY.
¹⁴ Vascular Biology Program, Boston Children's Hospital, Boston, MA and Department of Surgery, Harvard Medical School and Boston Children's Hospital, Boston, MA.
¹⁵ Department of Neurology, Barrow Neurological Institute, Phoenix Children's Hospital, Phoenix AZ.

PMID: 30482419
PMCID: PMC7288478
DOI: 10.1016/j.pediatrneurol.2018.04.009

No abstract available

Keywords: Cognitive deficits; Epilepsy; Intellectual disability; Presymptomatic; Seizures; Sturge-Weber syndrome.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Anticonvulsants / therapeutic use*
Aspirin / therapeutic use*
Disease Progression
Humans
Infant
Platelet Aggregation Inhibitors / therapeutic use*
Seizures / drug therapy
Seizures / prevention & control*
Sturge-Weber Syndrome / drug therapy*

Substances

Anticonvulsants
Platelet Aggregation Inhibitors
Aspirin

Grants and funding

U54 NS065705/NS/NINDS NIH HHS/United States