A mitochondria-targeted nitric oxide donor triggered by superoxide radical to alleviate myocardial ischemia/reperfusion injury

Chem Commun (Camb). 2019 Jan 24;55(9):1205-1208. doi: 10.1039/c8cc07304j.

Abstract

A novel mitochondria-targeted superoxide-responsive nitric oxide donor was developed by incorporation of diphenylphosphinyl and triphenylphosphonium groups into diazeniumdiolate, enabling remarkable protection against ischemia/reperfusion injury in H9c2 cells and isolated rat hearts.

MeSH terms

  • Animals
  • Cardiotonic Agents / chemical synthesis
  • Cardiotonic Agents / therapeutic use*
  • Free Radical Scavengers / chemical synthesis
  • Free Radical Scavengers / therapeutic use
  • Hydrazines / chemical synthesis
  • Hydrazines / therapeutic use
  • Male
  • Mitochondria / metabolism*
  • Myocardial Reperfusion Injury / drug therapy*
  • Myocardium / metabolism
  • Nitric Oxide / metabolism
  • Nitric Oxide Donors / chemical synthesis
  • Nitric Oxide Donors / therapeutic use*
  • Phosphinic Acids / chemical synthesis
  • Phosphinic Acids / therapeutic use
  • Rats, Wistar
  • Superoxides / chemistry*

Substances

  • Cardiotonic Agents
  • Free Radical Scavengers
  • Hydrazines
  • Nitric Oxide Donors
  • Phosphinic Acids
  • Superoxides
  • Nitric Oxide