The representation of place is a key theoretical advancement that Geographic Information Science can offer to improve the understanding of environmental determinants of health, but developing robust computational representations of place requires a substantial departure from conventional notions of geographic representation in Geographic Information Systems (GIS). Unlike conventional GIS representations based on either objects or locations, we suggest place representation should incorporate dynamic subjective, experiential, and relational aspects of place, as the influence of place on health behavior concerns not only the features that can be objectively observed at a particular location but also the environmental perceptions of the individual, as molded by biological, social, and experiential characteristics. In addition, assessments of environmental exposures on health outcomes should focus on individuals' time-activity patterns and microenvironment profiles, which form a potentially unique personalized exposure environment for each individual. Addressing these representational challenges via collaborative research has the potential to advance both Geographic Information Science and health research.