Analyzed the results of surgical treatment of 132 patients, including 68 — for cancer of the pancreatic head (in 46 — with jaundice) and 64 — chronic pancreatitis (CP) with a primary lesion of the pancreatic head (16 — with jaundice). The distribution of patients into groups was carried out with a maximum value of classification functions calculated by special formulas. Next studied indicators of endothelial dysfunction for differential diagnosis. A certain threshold of VEGF = 346 pg / ml, in which the patients were divid' ed into groups: СP and cancer on the pancreatic head. It was even more accurate indi' cator threshold VEGF = 248 pg / ml. To predict the severity of the pathological process, along with the use of diagnostic data, using the method of classification trees. Pancreatoduodenal resection for Whipple was performed in 23 patients, for Traverso— Longmire — in 8, subtotal right sided pancreatectomy for Fortner — in 3, hepaticoje' junostomy by Roux — in 8, duodenopreserving resection for Beger — in 6, her Bernese option — in 7, operation Frey — in 51. In 26 (19.7%) patients, minimally invasive inter' vention for removal of bile were spread through the final primary pathological process and severe general state. Postoperative complications occurred in 18 (13.6%) patients, died 3 (2.3%).