Establishing a human adrenocortical carcinoma (ACC)-specific gene mutation signature

Cancer Genet. 2019 Jan:230:1-12. doi: 10.1016/j.cancergen.2018.10.005. Epub 2018 Nov 9.

Abstract

Adrenocortical carcinoma (ACC) is a rare and aggressive tumor whose molecular signaling pathways are not fully understood. Using an in-silico clinical data analysis approach we retrieved human gene mutation data from the highly reputed Cancer Genome Atlas (TCGA). ACC-specific gene mutations were correlated with proliferation marker FAM72 expression and Mutsig along with the algorithmic implementation of the 20/20 rule were used to validate their oncogenic potential. The newly identified oncogenic driver gene set (ZFPM1, LRIG1, CRIPAK, ZNF517, GARS and DGKZ), specifically and most repeatedly mutated in ACC, is involved in tumor suppression and cellular proliferation and thus could be useful for the prognosis and development of therapeutic approaches for the treatment of ACC.

Keywords: Adrenal gland; CRIPAK; DGKZ; LRIG1; Oncogene; ZFPM1; Zinc finger.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adrenal Cortex Neoplasms / genetics*
  • Adrenal Cortex Neoplasms / mortality
  • Adrenocortical Carcinoma / genetics*
  • Adrenocortical Carcinoma / mortality
  • Adult
  • Aged
  • Aged, 80 and over
  • Biomarkers, Tumor / genetics*
  • Carcinogenesis / genetics*
  • Cell Line, Tumor
  • Computational Biology
  • DNA Mutational Analysis
  • Datasets as Topic
  • Female
  • Humans
  • Male
  • Middle Aged
  • Mutation
  • Sex Factors
  • Survival Analysis
  • Transcriptome / genetics*
  • Young Adult

Substances

  • Biomarkers, Tumor