Eicosanoid and Specialized Proresolving Mediator Regulation of Lymphoid Cells

Abstract

Eicosanoids and specialized proresolving mediators (SPMs) regulate leukocyte function and inflammation. They are ideally positioned at the interface of the innate and adaptive immune responses when lymphocytes interact with leukocytes. Receptors for leukotriene B₄ (LTB₄), prostaglandin E₂ (PGE₂), and SPMs are expressed on lymphocytes. Evidence points toward an essential role of these lipid mediators (LMs) in direct regulation of lymphocyte functions. SPMs, which include lipoxins, demonstrate comprehensive protective actions with lymphocytes. LTB₄ and PGE₂ regulation of lymphocytes is diverse and depends on the interaction of lymphocytes with other cells. Importantly, both LTB₄ and PGE₂ are essential regulators of T cell antitumor activity. These LMs are attractive therapeutic targets to control dysregulated innate and adaptive immune responses, promote lymphocyte antitumor activity, and prevent tumor immune evasion.