This review aims at a coherent summary of the results obtained from various studies that concern analgesic-like activity of the extracts of H. preforatum L and thirteen other Hypericum L. species (Hypericaceae). Botanical origin, plant organs and extraction modes of the plant material, experimental models, routes of administration and doses used for animal treatment are summarized. Mechanisms of action and substances (and even the synergy thereof) proposed so far to be responsible for the observed activity have also been discussed. Even though St. John's wort (H. perforatum) is the most renowned plant species of this genus, it is neither the only nor the most potent one in inducing pain relief.