Class 1 HDAC and HDAC6 inhibition inversely regulates CD38 induction in myeloma cells via interferon-α and ATRA

Br J Haematol. 2019 Jun;185(5):969-974. doi: 10.1111/bjh.15673. Epub 2018 Nov 26.

Authors

Ariunzaya Bat-Erdene¹, Shingen Nakamura¹, Asuka Oda¹, Masami Iwasa¹, Jumpei Teramachi^{1

2}, Mohannad Ashtar³, Takeshi Harada¹, Hirokazu Miki⁴, Hirofumi Tenshin^{1

3}, Masahiro Hiasa^{1

3}, Shiro Fujii¹, Kimiko Sogabe¹, Masahiro Oura¹, Kengo Udaka¹, Kumiko Kagawa¹, Sumiko Yoshida¹, Ken-Ichi Aihara¹, Kiyoe Kurahashi¹, Itsuro Endo¹, Masahiro Abe¹

Affiliations

¹ Department of Haematology, Endocrinology and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School of Medicine, Tokushima, Japan.
² Department of Tissue Regeneration, Tokushima University Graduate School of Oral Sciences, Tokushima, Japan.
³ Department of Orthodontics and Dentofacial Orthopaedics, Tokushima University Graduate School of Oral Sciences, Tokushima, Japan.
⁴ Division of Transfusion Medicine and Cell Therapy, Tokushima University Hospital, Tokushima, Japan.

PMID: 30474853
DOI: 10.1111/bjh.15673

No abstract available

Keywords: ATRA; CD38; HDAC inhibition; interferon-α; multiple myeloma.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

ADP-ribosyl Cyclase 1 / biosynthesis*
Antineoplastic Combined Chemotherapy Protocols / pharmacology*
Histone Deacetylase 6 / antagonists & inhibitors*
Histone Deacetylase 6 / metabolism
Histone Deacetylase Inhibitors / administration & dosage
Humans
Interferon-alpha / administration & dosage
Membrane Glycoproteins / biosynthesis*
Multiple Myeloma / drug therapy*
Multiple Myeloma / enzymology
Multiple Myeloma / metabolism
Tretinoin / administration & dosage

Substances

Histone Deacetylase Inhibitors
Interferon-alpha
Membrane Glycoproteins
Tretinoin
CD38 protein, human
ADP-ribosyl Cyclase 1
HDAC6 protein, human
Histone Deacetylase 6