Recent progresses on synthesized LuxS inhibitors: A mini-review

Bioorg Med Chem. 2019 Jan 1;27(1):36-42. doi: 10.1016/j.bmc.2018.11.026. Epub 2018 Nov 20.

Abstract

Design and synthesis of LuxS enzyme inhibitors otherwise known as S-ribosylhomocysteine analogues, to target quorum sensing in bacteria, has been considerably developed within the last decade. This review presents which molecules have been synthesized to target LuxS enzyme in other words inhibitors of S-ribosylhomocysteinase. It reports their tested biological activity as LuxS inhibitors when available. A systematic overview has been conducted by searching PubMed, Medline, and The Cochrane Library and data extraction of all synthesized S-ribosylhomocysteine analogues has been collected. This mini-review shows limited data to date on this area and should continue to be studied.

Keywords: Bacteria; LuxS enzyme; Quorum sensing; S-Ribosylhomocysteine.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents / chemical synthesis
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology*
  • Bacterial Proteins / antagonists & inhibitors*
  • Bacterial Proteins / chemistry
  • Carbon-Sulfur Lyases / antagonists & inhibitors*
  • Carbon-Sulfur Lyases / chemistry
  • Enzyme Inhibitors / chemical synthesis
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology*
  • Homocysteine / analogs & derivatives*
  • Homocysteine / chemical synthesis
  • Homocysteine / pharmacology
  • Quorum Sensing / drug effects

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Enzyme Inhibitors
  • S-ribosyl-L-homocysteine
  • Homocysteine
  • Carbon-Sulfur Lyases
  • LuxS protein, Bacteria