Traumatic experiences and cognitive profiles of schizophrenia cases influenced by the BDNF Val66met polymorphism

Psychiatry Res. 2019 Jan:271:111-113. doi: 10.1016/j.psychres.2018.11.029. Epub 2018 Nov 15.

Abstract

The association of early trauma exposure with current cognition was examined in a research series of 56 schizophrenia cases with respect to the BDNF Val66Met polymorphism (rs6265, Val66Val, Val66Met, Met66Met), as met allele carriers have reduced neurotrophic activity. The Perceptual Organization Index had a significant negative correlation with trauma exposures only in met carriers, including early physical abuse, general trauma after age 18 years, and physical abuse. Within the Val66Val subgroup, there were no significant correlations between WAIS indices and traumatic experiences.

Keywords: BDNF; Schizophrenia; Trauma.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Adult Survivors of Child Adverse Events / psychology*
  • Alleles*
  • Brain-Derived Neurotrophic Factor / genetics*
  • Case-Control Studies
  • Cognition*
  • Female
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide / genetics*
  • Schizophrenia / genetics*
  • Schizophrenic Psychology*
  • Young Adult

Substances

  • Brain-Derived Neurotrophic Factor
  • BDNF protein, human