Noncoding RNA activated by DNA damage (NORAD): Biologic function and mechanisms in human cancers

Zhi Yang; Yongqiang Zhao; Guofu Lin; Xiangyu Zhou; Xiaofeng Jiang; Haiying Zhao

doi:10.1016/j.cca.2018.11.025

Noncoding RNA activated by DNA damage (NORAD): Biologic function and mechanisms in human cancers

Clin Chim Acta. 2019 Feb:489:5-9. doi: 10.1016/j.cca.2018.11.025. Epub 2018 Nov 20.

Authors

Zhi Yang¹, Yongqiang Zhao¹, Guofu Lin¹, Xiangyu Zhou¹, Xiaofeng Jiang², Haiying Zhao³

Affiliations

¹ Department of General Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, China.
² Department of General Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, China. Electronic address: 18900912171@163.com.
³ Department of General Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, China. Electronic address: zhaohy0302@163.com.

PMID: 30468715
DOI: 10.1016/j.cca.2018.11.025

Abstract

Noncoding RNA activated by DNA damage (NORAD) is a newly identified long non-coding RNA (lncRNA) comprising one exon located on Chr20q11.23. NORAD is unique among lncRNAs because it is highly conserved, abundantly expressed, upregulated upon DNA damage, and maintains chromosomal stability in human cells. NORAD is dysregulated in different types of cancers and has been implicated in several processes correlated with carcinogenesis, such as cell proliferation, invasion, metastasis, and apoptosis. The mechanisms underlying the effects of NORAD are complex and involve multiple factors and signaling pathways. The biologic function and mechanisms of NORAD in human cancers are systematically reviewed here to provide new directions for future research.

Keywords: Cancer; Genome stability; Long non-coding RNA; NORAD; Oncogene; Tumor suppressor.

Publication types

Review

MeSH terms

DNA Damage / genetics*
Genomic Instability
Humans
Neoplasms / genetics*
RNA, Untranslated / genetics*

Substances

RNA, Untranslated