Repeat kidney transplant recipients with active rejection have elevated donor-derived cell-free DNA

Am J Transplant. 2019 May;19(5):1597-1598. doi: 10.1111/ajt.15192. Epub 2018 Dec 10.

Authors

Shikha G Mehta¹, Jae H Chang², Tarek Alhamad³, Jonathan S Bromberg⁴, David J Hiller⁵, Marica Grskovic⁵, James P Yee⁵, Roslyn B Mannon¹

Affiliations

¹ Division of Nephrology, Department of Medicine, University of Alabama School of Medicine, Birmingham, Alabama.
² Columbia University Medical Center, New York, New York.
³ Washington University, St. Louis, Missouri.
⁴ Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland.
⁵ CareDx, Brisbane, California.

No abstract available

Keywords: acute; antibody-mediated (ABMR); clinical research/practice; immune; kidney transplantation/nephrology; monitoring; rejection.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Cell-Free Nucleic Acids / adverse effects*
Cell-Free Nucleic Acids / blood
Graft Rejection / blood
Graft Rejection / etiology*
Graft Rejection / pathology
Graft Survival
Humans
Isoantibodies / adverse effects*
Kidney Transplantation / adverse effects*
Kidney Transplantation / statistics & numerical data*
Prognosis
Tissue Donors / supply & distribution*
Transplant Recipients / statistics & numerical data*

Substances

Cell-Free Nucleic Acids
Isoantibodies

Grants and funding

CareDx/International