Early-Onset Inflammatory Bowel Disease

Judith R Kelsen; Pierre Russo; Kathleen E Sullivan

doi:10.1016/j.iac.2018.08.008

Early-Onset Inflammatory Bowel Disease

Immunol Allergy Clin North Am. 2019 Feb;39(1):63-79. doi: 10.1016/j.iac.2018.08.008.

Authors

Judith R Kelsen¹, Pierre Russo², Kathleen E Sullivan³

Affiliations

¹ Division of Gastroenterology, Hepatology and Nutrition, 3401 Civic Center Boulevard, Philadelphia, PA 19104, USA.
² Department of Pathology, Division of Allergy Immunology, The Children's Hospital of Philadelphia, ARC 1216-I, 3615 Civic Center Boulevard, Philadelphia, PA 19104, USA.
³ Division of Allergy Immunology, The Children's Hospital of Philadelphia, 3615 Civic Center Boulevard, Philadelphia, PA 19104, USA. Electronic address: sullivank@email.chop.edu.

Abstract

The epidemiology of inflammatory bowel disease has changed over the past 4 decades. The incidence is rising dramatically and the age of onset has become younger. This changing landscape of inflammatory bowel disease reflects the new recognition that the youngest children with inflammatory bowel disease are enriched in cases with underlying primary immunodeficiency and monogenic causes. The management of these cases can be quite different, with specific genetic etiologies supporting unique interventions and some requiring hematopoietic cell transplantation for effective treatment.

Keywords: Inflammation; Monogenic; Primary immunodeficiencies; VEO-IBD.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Age of Onset
Autoimmunity
Diagnosis, Differential
Disease Susceptibility
Genetic Association Studies
Genetic Predisposition to Disease
Humans
Inflammatory Bowel Diseases / diagnosis*
Inflammatory Bowel Diseases / epidemiology*
Inflammatory Bowel Diseases / etiology
Phenotype

Grants and funding

K23 DK100461/DK/NIDDK NIH HHS/United States