Studies have shown that Chinese herb caulis extract can effectively inhibit the expression of the core regulatory hormone hepcidin in iron metabolism and significantly increase the iron level in the body. On this basis, this paper analyzed clinical efficacy and safety of oral niferex (polysaccharide iron complex) combined with caulis Decoction in the treatment of iron deficiency anemia. The results showed that the recovery rate of the Caulis group, Niferex group and the combined treatment group were 41.6%, 46.6% and 58.3% respectively. The difference of recovery rate was statistically significant. The RBC, Hb, Hct, SI, SF, Tf, TIBC and serum Hepcidin in the combined treatment group were significantly higher than those in the other groups (P<0.05). Caulis group has 3 cases of gastrointestinal symptoms, and the incidence of adverse reactions was 5%. Chinese medicine caulis can significantly improve erythrocyte count, hemoglobin, hematocrit and related iron metabolism, but the improvement of the combined treatment group is more obvious. In conclusion, Chinese medicine caulis can significantly improves the clinical symptoms and iron metabolism in patients with iron deficiency anemia, combined oral niferex therapy has better effect.