Utility of histology for the diagnosis of portal hypertensive gastroenteropathy. Concordance between the endoscopic image and gastrointestinal biopsies. Role of the CD34 marker
Gastroenterol Hepatol. 2019 Mar;42(3):150-156.
doi: 10.1016/j.gastrohep.2018.09.008.
Epub 2018 Nov 17.
[Article in
English,
Spanish]
Authors
Maria Rosa Bella
1
, Meritxell Casas
2
, Mercedes Vergara
3
, Enric Brullet
4
, Félix Junquera
4
, Eva Martínez-Bauer
2
, Mireia Miquel
4
, Jordi Sánchez-Delgado
4
, Blai Dalmau
2
, Rafael Campo
4
, Xavier Calvet
4
Affiliations
- 1 Servicio de Anatomía Patológica, Parc Taulí Hospital Universitari, Institut d'Investigació i Innovació Parc Taulí I3PT, Universitat Autònoma de Barcelona, Sabadell, Barcelona, España.
- 2 Servicio de Aparato Digestivo, Parc Taulí Hospital Universitari, Institut d'Investigació i Innovació Parc Taulí I3PT, Universitat Autònoma de Barcelona, Sabadell, Barcelona, España.
- 3 Servicio de Aparato Digestivo, Parc Taulí Hospital Universitari, Institut d'Investigació i Innovació Parc Taulí I3PT, Universitat Autònoma de Barcelona, Sabadell, Barcelona, España; Centro de Investigación biomédica y en Red Enfermedades hepáticas y digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, España. Electronic address: mvergara@tauli.cat.
- 4 Servicio de Aparato Digestivo, Parc Taulí Hospital Universitari, Institut d'Investigació i Innovació Parc Taulí I3PT, Universitat Autònoma de Barcelona, Sabadell, Barcelona, España; Centro de Investigación biomédica y en Red Enfermedades hepáticas y digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, España.
Abstract
Introduction:
Upper gastroscopy in patients with cirrhosis often reveals non-specific lesions, which are usually oriented as portal hypertensive gastropathy (PHG). However, the diagnosis of PHG can be difficult, both from an endoscopic and histological point of view. The study of CD34 expression, which enhances the endothelial cells of the microvasculature, could help the differential diagnosis. The objectives of this study were to evaluate the correlation between endoscopy and histology in the diagnosis of PHG and to assess the utility of CD34 in the diagnosis of PHG.
Material and methods:
The results of immunostaining with CD34 gastric fundus biopsies from 100 cirrhotic patients and 20 controls were compared with the endoscopic images.
Results:
The correlation between the histology and the endoscopic diagnosis of PHG was very low (kappa=0.15). In addition, the measurement of the diameter of the gastric vessels enhanced by the use of immunohistochemical staining (CD34) did not show good correlation with the endoscopic diagnosis (p=.26) and did not provide relevant information for the histological diagnosis of PHG either.
Discussion:
The correlation between histology and endoscopy is low for the diagnosis of PHG. The use of immunostaining for CD34 does not seem to improve the diagnostic yield of the histological study.
Keywords:
Biopsias; Biopsies; CD34; Concordance; Concordancia; Gastropathy; Gastropatía; Histology; Histología; Immunohistochemistry; Inmunohistoquímica.
Copyright © 2018 Elsevier España, S.L.U. All rights reserved.
Publication types
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Comparative Study
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Evaluation Study
MeSH terms
-
Adult
-
Aged
-
Aged, 80 and over
-
Antigens, CD34 / analysis*
-
Biomarkers / analysis
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Biopsy
-
Case-Control Studies
-
Diagnosis, Differential
-
Female
-
Gastric Fundus / blood supply
-
Gastric Fundus / immunology
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Gastric Fundus / pathology
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Gastroscopy / methods
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Humans
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Hypertension, Portal / complications*
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Hypertension, Portal / metabolism
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Liver Cirrhosis / complications*
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Male
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Middle Aged
-
Stomach / pathology
-
Stomach Diseases / diagnosis*
-
Stomach Diseases / etiology
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Stomach Diseases / metabolism
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Stomach Diseases / pathology*
Substances
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Antigens, CD34
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Biomarkers