In-Host Adaptation of Salmonella enterica Serotype Dublin during Prosthetic Hip Joint Infection

Emerg Infect Dis. 2018 Dec;24(12):2360-2363. doi: 10.3201/eid2412.180214.

Abstract

Genome degradation has been central to the adaptation of Salmonella enterica serotypes to their hosts throughout evolution. We witnessed the patho-adaptation of a strain of Salmonella Dublin (a cattle-adapted serotype) to a human host during the course of a recurrent prosthetic hip joint infection evolving over several years.

Keywords: France; Salmonella enterica serotype Dublin; adaptation; bacteria; bone and joint infection; epidemiology.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptation, Biological*
  • Aged
  • Female
  • Genes, Bacterial
  • Genome, Bacterial
  • Hip Prosthesis / adverse effects*
  • Host-Pathogen Interactions*
  • Humans
  • Microbial Sensitivity Tests
  • Phenotype
  • Phylogeny
  • Prosthesis-Related Infections / diagnosis
  • Prosthesis-Related Infections / drug therapy
  • Prosthesis-Related Infections / microbiology*
  • Salmonella Infections / diagnosis
  • Salmonella Infections / drug therapy
  • Salmonella Infections / microbiology*
  • Salmonella enterica / classification*
  • Salmonella enterica / drug effects
  • Salmonella enterica / physiology*