Fetal membrane architecture, aging and inflammation in pregnancy and parturition

Ramkumar Menon; Lauren S Richardson; Martha Lappas

doi:10.1016/j.placenta.2018.11.003

Fetal membrane architecture, aging and inflammation in pregnancy and parturition

Placenta. 2019 Apr:79:40-45. doi: 10.1016/j.placenta.2018.11.003. Epub 2018 Nov 10.

Authors

Ramkumar Menon¹, Lauren S Richardson², Martha Lappas³

Affiliations

¹ Division of Maternal-Fetal Medicine & Perinatal Research, Department of Obstetrics & Gynecology, The University of Texas Medical Branch at Galveston, Galveston, TX, USA. Electronic address: ram.menon@utmb.edu.
² Division of Maternal-Fetal Medicine & Perinatal Research, Department of Obstetrics & Gynecology, The University of Texas Medical Branch at Galveston, Galveston, TX, USA.
³ Obstetrics, Nutrition and Endocrinology Group, Department of Obstetrics and Gynaecology, University of Melbourne, Mercy Hospital for Women, Heidelberg, Victoria, Australia; Department of Obstetrics and Gynaecology, University of Melbourne, Mercy Hospital for Women, Heidelberg, Victoria, Australia. Electronic address: mlappas@unimelb.edu.au.

Abstract

Preterm birth is the single major cause of infant mortality. Short and long term outcomes for infants are often worse in cases of preterm premature rupture of the fetal membranes (pPROM). Thus, increased knowledge of the structure characteristics of fetal membranes as well as the mechanisms of membrane rupture are essential if we are to develop effective treatment strategies to prevent pPROM. In this review, we focus on the role of inflammation and senescence in fetal membrane biology.

Keywords: Fetal membranes; Inflammation; Senescence; Structure.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Cellular Senescence*
Extraembryonic Membranes / growth & development*
Female
Humans
Inflammation*
Pregnancy
Premature Birth / etiology*
Premature Birth / prevention & control
Term Birth*

Abstract

Publication types

MeSH terms

Grants and funding