[A new naphthaldehyde derivative from Comastoma pulmonarium and its anti-tobacco mosaic virus (anti-TMV) activity]

Zhongguo Zhong Yao Za Zhi. 2018 Oct;43(19):3884-3886. doi: 10.19540/j.cnki.cjcmm.20180807.009.
[Article in Chinese]

Abstract

A new naphthaldehyde derivative has been isolated from Comastoma pulmonarium by using various chromatographic techniques, including silica gel, Sephadex LH-20, MCI-gel resin and RP-HPLC. This compounds was determined as 5-methoxy-2-methyl-7-(2-oxopropyl)naphthalene-1-carbaldehyde(1) by NMR, MS, IR and UV spectra. This compound was also evaluated for its anti-tobacco mosaic virus (anti-TMV) activity. The result showed that it showed high anti-TMV activity with inhibition rate of 32.8%. The inhibition rate is close to that of positive control (ningnanmycin).

Keywords: Comastoma pulmonarium; anti-tobacco mosaic virus activity; naphthaldehyde.

MeSH terms

  • Aldehydes / isolation & purification
  • Aldehydes / pharmacology*
  • Antiviral Agents / isolation & purification
  • Antiviral Agents / pharmacology*
  • Chromatography, High Pressure Liquid
  • Gentianaceae / chemistry*
  • Naphthalenes / isolation & purification
  • Naphthalenes / pharmacology*
  • Nicotiana
  • Phytochemicals / isolation & purification
  • Phytochemicals / pharmacology
  • Tobacco Mosaic Virus / drug effects*

Substances

  • Aldehydes
  • Antiviral Agents
  • Naphthalenes
  • Phytochemicals