Objective: Introduction: Uric acid (UA) is the risk factors for the development of arterial hypertension (AH). Development of alternative methods of UA level reduction becomes relevant. The aim - to determine the correlation between UA and endothelial dysfunction and blood pressure level (BP), and to evaluate the effectiveness of low level laser therapy (LLLT).
Patients and methods: Material and methods: Patients were divided according to the BP level: the first group included 30 patients with the hyperuricemia and normal BP; the second group - 34 patients with hyperuricemia and AH. Endothelium function was evaluated by test with reactive hyperemia. LLLT was provided by using of the apparatus "Mustang-2000" with wavelength 635 nm.
Results: Results: There is a mean value negative correlation on the Chaddock's scale r = - 0,6209 between UA and ED; a mean value positive correlation r = 0,48 between UA and daySBP; a weak positive correlation r = 0,33 between UA and DayDBP. LLLT reduces UA level by 4,7% more effective in patients with hyperuricemia without AH than in patients with AH combined with hyperuricemia. LLLT can increase EDVD by 9,87%, reduce UA level by 15,4%, DaySBP and DayDBP - about 7% in patients with AH combined with hyperuricemia than in patients with hyperuricemia along.
Conclusion: Conclusion: Decreasing of DayDBP in hyperuricemia group and both DaySBP and DayDBP in the group of patients with AH combined with hyperuricemia demonstrated the influence of UA on EDVD and AH and the possibility to correct these cardiovascular risk factors with the using of LLLT.
Keywords: LLLT; arterial hypertension; endothelial dysfunction; hyperuricemia; low level laser therapy; uric acid.