Engineering Microorganisms for Enhanced CO2 Sequestration

Guipeng Hu; Yin Li; Chao Ye; Liming Liu; Xiulai Chen

doi:10.1016/j.tibtech.2018.10.008

Engineering Microorganisms for Enhanced CO₂ Sequestration

Trends Biotechnol. 2019 May;37(5):532-547. doi: 10.1016/j.tibtech.2018.10.008. Epub 2018 Nov 15.

Authors

Guipeng Hu¹, Yin Li², Chao Ye¹, Liming Liu³, Xiulai Chen⁴

Affiliations

¹ State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; Key Laboratory of Industrial Biotechnology, Ministry of Education, Jiangnan University, Wuxi 214122, China; http://www.fmme.cn/.
² CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
³ State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; Key Laboratory of Industrial Biotechnology, Ministry of Education, Jiangnan University, Wuxi 214122, China; National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, Wuxi 214122, China; http://www.fmme.cn/.
⁴ State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; Key Laboratory of Industrial Biotechnology, Ministry of Education, Jiangnan University, Wuxi 214122, China; http://www.fmme.cn/. Electronic address: xlchen@jiangnan.edu.cn.

PMID: 30447878
DOI: 10.1016/j.tibtech.2018.10.008

Abstract

Microbial CO₂ sequestration not only provides a green and sustainable approach for ameliorating global warming but also simultaneously produces biofuels and chemicals. However, the efficiency of microbial CO₂ fixation is still very low. In addition, concomitant microbial CO₂ emission decreases the carbon yield of desired chemicals. To address these issues, strategies including engineering CO₂-fixing pathways and energy-harvesting systems have been developed to improve the efficiency of CO₂ fixation in autotrophic and heterotrophic microorganisms. Furthermore, metabolic pathways and energy metabolism can be rewired to reduce microbial CO₂ emissions and increase the carbon yield of value-added products. This review highlights the potential of biotechnology to promote microbial CO₂ sequestration and provides guidance for the broader use of microorganisms as attractive carbon sinks.

Keywords: CO(2) emission; CO(2) fixation; CO(2) sequestration; metabolic engineering; metabolic pathway; microbial engineering.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Bacteria* / genetics
Bacteria* / metabolism
Carbon Dioxide* / isolation & purification
Carbon Dioxide* / metabolism
Carbon Sequestration*
Metabolic Engineering*

Substances

Carbon Dioxide