Bromocatechol conjugates from a Chinese marine red alga, Symphyocladia latiuscula

Abstract

This study describes an investigation into polybromocatechol conjugates isolated from a marine red alga, Symphyocladia latiuscula (Harvey) Yamada, collected from coastal waters off Qingdao, China. We report on the isolation and characterisation of eight undescribed aconitic acid conjugates, symphyocladins R-X, including a likely solvolysis artifact of symphyocladin S, and an undescribed furanoyl conjugate, symphyocladin Y. Structure elucidation was achieved by detailed spectroscopic analysis. A plausible biosynthetic pathway linking all these co-metabolites through a cascade of quinone methide additions is proposed.

Keywords: Bromocatechol; Bromophenol; Natural products; Quinone methide; Red alga; Symphyocladia latiuscula (Rhodomelaceae).