Signaling Size: Ankyrin and SOCS Box-Containing ASB E3 Ligases in Action

Pengyu Liu; Auke P Verhaar; Maikel P Peppelenbosch

doi:10.1016/j.tibs.2018.10.003

Signaling Size: Ankyrin and SOCS Box-Containing ASB E3 Ligases in Action

Trends Biochem Sci. 2019 Jan;44(1):64-74. doi: 10.1016/j.tibs.2018.10.003. Epub 2018 Nov 13.

Authors

Pengyu Liu¹, Auke P Verhaar¹, Maikel P Peppelenbosch²

Affiliations

¹ Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
² Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands. Electronic address: m.peppelenbosch@erasmusmc.nl.

PMID: 30446376
DOI: 10.1016/j.tibs.2018.10.003

Abstract

Ankyrin repeat and suppressor of cytokine signaling (SOCS) box (Asb) proteins are ubiquitin E3 ligases. The subfamily of six-ankyrin repeat domain-containing Asb proteins (Asb5, Asb9, Asb11, and Asb13) is of specific interest because they display unusual strong evolutionary conservation (e.g., urochordate and human ASB11 are >49% similar at the amino acid level) and mediate compartment size expansion, regulating, for instance, the size of the brain and muscle compartment. Thus, they may be involved in the explanation of the differences in brain size between humans and apes. Mechanistically, many questions remain, but it has become clear that regulation of canonical Notch signaling and also mitochondrial function are important effectors. Here, we review the action and function of six ankyrin repeat domain-containing Asb proteins in physiology and pathophysiology.

Keywords: Asb subgroup; Notch signaling; compartment size; muscle; ubiquitination.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Ankyrins / metabolism*
Humans
Signal Transduction*
Suppressor of Cytokine Signaling Proteins / metabolism*
Ubiquitin-Protein Ligases / metabolism*

Substances

Ankyrins
Suppressor of Cytokine Signaling Proteins
Ubiquitin-Protein Ligases