Histone Modifications: Epigenetic Mediators of Environmental Exposure Memory

Epigenet Insights. 2018 Oct 14:11:2516865718803641. doi: 10.1177/2516865718803641. eCollection 2018.

Abstract

How organisms retain a memory of ancestral environmental exposure is a phenomenon that is still poorly understood. Recently published work by our group and others, regarding environmentally induced transgenerational effects, have identified an array of mechanisms, with a particular focus on histone modifications, that shed some light on the underlying epigenetic processes driving long-term generational effects.

Keywords: Bisphenol A; C. elegans; histone demethylase; reproductive function; transgenerational inheritance.