A Novel MRI-Based Radiomics Model for Predicting Recurrence in Chordoma

Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul:2018:139-142. doi: 10.1109/EMBC.2018.8512207.

Abstract

Chordoma is a rare primary malignant tumor. For evaluating the related factors of postoperative recurrence probability of chordoma before surgery, we retrospective collected 80 patients to analyze by using a novel radiomics method. A total of 620 3D imaging features used for radiomics analysis were extracted, and 5 features were selected from T2-weighted (T2-w) magnetic resonance imaging (MRI) that were most strongly associated with 4-year recurrence probability to build a radiomics signature. Verification by logistic regression classification model, the area under the receiver operating characteristic curve and accuracy was 0.8600 (95% CI: 0.7226-0.9824) and 85.00% in the training cohort, respectively, while in the validation cohort was 0.8568 (95% CI: 0.7327-0.9758) and 85.00%. Experimental results show that T2-w MRI-based radiomics signature is closely associated with the recurrence of chordoma. It is possible to prejudge the recurrence of chordoma before surgery.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chordoma* / diagnostic imaging
  • Cohort Studies
  • Humans
  • Logistic Models
  • Magnetic Resonance Imaging* / methods
  • Neoplasm Recurrence, Local
  • ROC Curve
  • Retrospective Studies