Genetic polymorphism contributes to 131I radiotherapy-induced toxicities in patients with differentiated thyroid cancer

Jianqiu Liu; Xinyue Tang; Feng Shi; Cuilin Li; Ke Zhang; Jie Liu; Guo Wang; Jiye Yin; Zhi Li

doi:10.2217/pgs-2018-0070

Genetic polymorphism contributes to ¹³¹I radiotherapy-induced toxicities in patients with differentiated thyroid cancer

Pharmacogenomics. 2018 Nov;19(17):1335-1344. doi: 10.2217/pgs-2018-0070. Epub 2018 Oct 16.

Authors

Jianqiu Liu^{1

2}, Xinyue Tang^{1

2

3}, Feng Shi⁴, Cuilin Li^{1

2}, Ke Zhang^{1

2}, Jie Liu^{1

2}, Guo Wang^{1

2}, Jiye Yin^{1

2}, Zhi Li^{1

2}

Affiliations

¹ Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, PR China.
² Institute of Clinical Pharmacology, Central South University & Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, PR China.
³ Department of Center for ADR Monitoring of Hubei, Wuhan 430071, PR China.
⁴ Department of Thyroid internal medicine, Hunan Cancer Hospital & the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, PR China.

PMID: 30430914
DOI: 10.2217/pgs-2018-0070

Abstract

Aim: To investigate the association between SNPs in DNA damage response pathways and toxicities following ¹³¹I radiotherapy of differentiated thyroid cancer (DTC). Materials & methods: We identified 22 functional SNPs of genes in DNA damage response pathways. MassArray was used to sequence SNP genotypes in 203 DTC patients. Hardy-Weinberg equilibrium and the associations between the two alleles of each SNP and toxicity reactions were evaluated using χ² analysis.

Results: Ataxia-telangiectasia mutated (ATM) rs620815 T-allele carriers were at increased risk of ¹³¹I radiation-induced gastrointestinal reaction compared with C allele carriers. TNFα rs1800629 GA genotype may increase the incidence of neck pain compared with GG genotype. Furthermore, TNFα rs1800629, ATM rs11212570, NF-κβ rs230493, and TGF-β rs1800469, rs2241716 were associated with throat pain following ¹³¹I radiotherapy.

Conclusion: The identified SNPs might serve as novel biomarkers for DTC treated with ¹³¹I radiotherapy.

Keywords: 131I radiotherapy; SNPs; toxicity reactions.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alleles
Ataxia Telangiectasia Mutated Proteins / genetics
Female
Genotype
Heterozygote
Humans
Iodine Radioisotopes / adverse effects*
Male
Middle Aged
Polymorphism, Single Nucleotide / genetics*
Radiation Injuries / genetics*
Thyroid Neoplasms / genetics*
Thyroid Neoplasms / radiotherapy

Substances

Iodine Radioisotopes
Ataxia Telangiectasia Mutated Proteins