Electrospun bimetallic Au-Ag/Co3O4 nanofibers for sensitive detection of hydrogen peroxide released from human cancer cells

Yuting Zhang; Dongmei Deng; Xiaoli Zhu; Shuai Liu; Yan Zhu; Long Han; Liqiang Luo

doi:10.1016/j.aca.2018.07.065

Electrospun bimetallic Au-Ag/Co₃O₄ nanofibers for sensitive detection of hydrogen peroxide released from human cancer cells

Anal Chim Acta. 2018 Dec 26:1042:20-28. doi: 10.1016/j.aca.2018.07.065. Epub 2018 Jul 27.

Authors

Yuting Zhang¹, Dongmei Deng², Xiaoli Zhu³, Shuai Liu⁴, Yan Zhu⁵, Long Han⁵, Liqiang Luo⁶

Affiliations

¹ College of Sciences, Shanghai University, Shanghai, 200444, PR China; Institute of Complex Systems (ICS-8), Forschungszentrum Jülich, Jülich, 52425, Germany.
² College of Sciences, Shanghai University, Shanghai, 200444, PR China. Electronic address: dmdeng@shu.edu.cn.
³ Laboratory of Biosensing Technology, School of Life Sciences, Shanghai University, Shanghai, 200444, PR China.
⁴ Institute of Complex Systems (ICS-8), Forschungszentrum Jülich, Jülich, 52425, Germany.
⁵ College of Sciences, Shanghai University, Shanghai, 200444, PR China.
⁶ College of Sciences, Shanghai University, Shanghai, 200444, PR China. Electronic address: luck@shu.edu.cn.

PMID: 30428984
DOI: 10.1016/j.aca.2018.07.065

Abstract

Bimetallic Au-Ag/Co₃O₄ nanofibers (Au-Ag/Co₃O₄NFs) were synthesized by an electrospinning method and calcination treatment. Due to the admirable synergic effect of electrocatalytic ability of Au and Ag, and the large surface-to-volume ratio of Co₃O₄ nanofibers caused by their rough surface, the synthesized Au-Ag/Co₃O₄NFs were applied to a sensing platform for hydrogen peroxide oxidation. Using electrochemical techniques, the novel sensing platform based on Au-Ag/Co₃O₄NFs shows a wide linear concentration range with high detection sensitivity of 1241.1 μA mM^-1 cm^-2. This sensitive sensor was also applied to determine H₂O₂ from human breast cancer cells, indicating its great potential application in physiology and pathology.

Keywords: Bimetallic Au-Ag; Electrocatalysis; Electrospinning; Nanofibers; Spinel-type.

MeSH terms

Breast Neoplasms / metabolism*
Breast Neoplasms / pathology
Cobalt / chemistry*
Female
Gold / chemistry*
Humans
Hydrogen Peroxide / analysis*
Hydrogen Peroxide / metabolism*
Nanofibers / chemistry*
Oxides / chemistry*
Particle Size
Silver / chemistry*
Surface Properties

Substances

Oxides
Cobalt
Silver
Gold
Hydrogen Peroxide
cobalt oxide