Theranostics Applications of Nanoparticles in Cancer Immunotherapy

Yihai Liu; Xixi Wang; Mubashir Hussain; Mu Lv; Xiaohan Dong; Tianying Wang; Xueqin Xu; Bin Liu

doi:10.3390/medsci6040100

Theranostics Applications of Nanoparticles in Cancer Immunotherapy

Med Sci (Basel). 2018 Nov 9;6(4):100. doi: 10.3390/medsci6040100.

Authors

Yihai Liu¹, Xixi Wang², Mubashir Hussain³, Mu Lv⁴, Xiaohan Dong⁵, Tianying Wang⁶, Xueqin Xu⁷, Bin Liu^{8

9}

Affiliations

¹ Department of Biomedical Engineering, School of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing 211166, China. lyh1204913205@gmail.com.
² Department of Biomedical Engineering, School of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing 211166, China. wxxwq666@163.com.
³ State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China. mubashir_tuf@hotmail.com.
⁴ Department of Biomedical Engineering, School of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing 211166, China. 15651738713@163.com.
⁵ Department of Biomedical Engineering, School of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing 211166, China. xiaohantung@163.com.
⁶ Department of Biomedical Engineering, School of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing 211166, China. wty0118@icloud.com.
⁷ Department of Biomedical Engineering, School of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing 211166, China. jiuajiu9@outlook.com.
⁸ Department of Biomedical Engineering, School of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing 211166, China. liubin@njmu.edu.cn.
⁹ Key Laboratory of Clinical Medical Engineering, Nanjing Medical University, Nanjing 211166, China. liubin@njmu.edu.cn.

Abstract

With the advancement in the mechanism of immune surveillance and immune evasion in cancer cells, cancer immunotherapy shows promising results for treating cancer with established efficacy and less toxicity. As a result of the off-target effect, the approach for delivering vaccines, adjuvants, or antibodies directly to tumor sites is gaining widespread attention. An effective alternative is to utilize nanoengineered particles, functioning as drug-delivery systems or as antigens themselves. This article reviews the practical implementation of nanotechnology in cancer immunotherapy.

Keywords: cancer; immune evasion; immunotherapy; nanoparticles.

Publication types

Review

Abstract

Publication types

Grants and funding