Abstract
The first chain-Like vibralactone derivative, vibralactone Z4 (1), together with three known ones (2-4), were isolated from cultures of the basidiomycete Boreostereum vibrans. Vibralactone Z4 (1) is likely to be a key intermediate from 3 to 4 in their biosynthetic pathway. It showed a weak cytotoxicity to human cancer cell line SW480 (IC50 29.2 ± 1.38 μM).
Keywords:
cytotoxicity; vibralactone derivatives.
MeSH terms
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Basidiomycota / cytology
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Basidiomycota / metabolism*
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Biosynthetic Pathways
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Cell Line, Tumor
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Drug Screening Assays, Antitumor
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Humans
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Lactones / chemistry
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Lactones / metabolism*
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Lactones / pharmacology*
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Spectrometry, Mass, Electrospray Ionization
Substances
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Antineoplastic Agents
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Lactones
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vibralactone