Evolving Role of MR Imaging and PET in Assessing Osteoporosis

Alecxih G Austin; William Y Raynor; Catherine C Reilly; Mahdi Zirakchian Zadeh; Thomas J Werner; Hongming Zhuang; Abass Alavi; Chamith S Rajapakse

doi:10.1016/j.cpet.2018.08.007

Evolving Role of MR Imaging and PET in Assessing Osteoporosis

PET Clin. 2019 Jan;14(1):31-41. doi: 10.1016/j.cpet.2018.08.007. Epub 2018 Oct 24.

Authors

Alecxih G Austin¹, William Y Raynor¹, Catherine C Reilly¹, Mahdi Zirakchian Zadeh¹, Thomas J Werner¹, Hongming Zhuang¹, Abass Alavi¹, Chamith S Rajapakse²

Affiliations

¹ Department of Radiology, University of Pennsylvania, 3400 Spruce Street, MRI Education Center, 1 Founders Building, 253 South 45th Street, Philadelphia, PA 19104, USA.
² Department of Radiology, University of Pennsylvania, 3400 Spruce Street, MRI Education Center, 1 Founders Building, 253 South 45th Street, Philadelphia, PA 19104, USA. Electronic address: chamith@pennmedicine.upenn.edu.

PMID: 30420220
DOI: 10.1016/j.cpet.2018.08.007

Abstract

An imbalance in bone remodeling results in many metabolic bone diseases, such as osteoporosis. fluorine-18 sodium fluoride PET imaging allows the assessment of bone remodeling process in a anatomy specific manner. On the other hand structural imaging modalities such as MRI can now generate high resolution images of bone including the trabecular and cortical microstructure. Molecular (functional) imaging with PET in conjunction with structural imaging has the potential to improve the way metabolic bone diseases are managed in the clinic.

Keywords: Bone; MRI; NaF; Osteoporosis.

Publication types

Review

MeSH terms

Humans
Magnetic Resonance Imaging / methods*
Osteoporosis / diagnostic imaging*
Positron-Emission Tomography / methods*