Roles of DDX5 in the tumorigenesis, proliferation, differentiation, metastasis and pathway regulation of human malignancies

Rose Magoma Nyamao; Jing Wu; Li Yu; Xiao Xiao; Feng-Min Zhang

doi:10.1016/j.bbcan.2018.11.003

Roles of DDX5 in the tumorigenesis, proliferation, differentiation, metastasis and pathway regulation of human malignancies

Biochim Biophys Acta Rev Cancer. 2019 Jan;1871(1):85-98. doi: 10.1016/j.bbcan.2018.11.003. Epub 2018 Nov 9.

Authors

Rose Magoma Nyamao¹, Jing Wu², Li Yu³, Xiao Xiao³, Feng-Min Zhang⁴

Affiliations

¹ Department of Microbiology, Harbin Medical University, Harbin, China; Department of Pathology, Kenyatta University, Nairobi, Kenya.
² Department of Microbiology, Harbin Medical University, Harbin, China; Wu Lien-Teh Institute, Harbin Medical University, Harbin, China; Heilongjiang Province Key Laboratory of Immunity and Infection, Pathogenic Biology, Harbin, China.
³ Department of Microbiology, Harbin Medical University, Harbin, China.
⁴ Department of Microbiology, Harbin Medical University, Harbin, China; Wu Lien-Teh Institute, Harbin Medical University, Harbin, China; Heilongjiang Province Key Laboratory of Immunity and Infection, Pathogenic Biology, Harbin, China. Electronic address: fengminzhang@ems.hrbmu.edu.cn.

PMID: 30419318
DOI: 10.1016/j.bbcan.2018.11.003

Abstract

The DEAD-box RNA helicase DDX5 is a member of a family of highly conserved proteins involved in gene-expression regulation and ATP-dependent RNA helicase activities. Recently, it has been reported to be aberrantly expressed in many tumors, and is linked to the regulation of many cancer-related pathways. It co-activates many transcription factors, with profound implications for cancer development, and the de-regulation of its functions is ultimately associated with tumor formation and progression. Moreover, it is strongly implicated in the tumorigenesis, invasiveness and metastasis, as well as the proliferation of several cancer types. In this review, we seek to elucidate the role of DDX5 in the development and progression of human malignancies and put forward its prospective applications in future cancer research.

Keywords: DDX5; apoptosis; human malignancies; tumorigenesis.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Carcinogenesis / metabolism
Cell Differentiation / physiology
Cell Proliferation / physiology
DEAD-box RNA Helicases / metabolism*
Gene Expression Regulation, Neoplastic / physiology*
Humans
Neoplasm Invasiveness / pathology
Neoplasms / metabolism*
Neoplasms / pathology*

Substances

Ddx5 protein, human
DEAD-box RNA Helicases