Fluorescence Imaging for Minimally Invasive Cancer Surgery

Takeaki Ishizawa; Akio Saiura

doi:10.1016/j.soc.2018.08.001

Fluorescence Imaging for Minimally Invasive Cancer Surgery

Surg Oncol Clin N Am. 2019 Jan;28(1):45-60. doi: 10.1016/j.soc.2018.08.001. Epub 2018 Oct 23.

Authors

Takeaki Ishizawa¹, Akio Saiura²

Affiliations

¹ Department of Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo 135-8655, Japan. Electronic address: tish-tky@umin.ac.jp.
² Department of Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo 135-8655, Japan.

PMID: 30414681
DOI: 10.1016/j.soc.2018.08.001

Abstract

This article demonstrates surgical techniques of intraoperative fluorescence imaging using indocyanine green, focusing on its application in minimally invasive hepatobiliary and pancreatic surgery. In this area, indocyanine green fluorescence imaging has been applied to liver cancer identification, fluorescence cholangiography, delineation of hepatic segments, and fluorescence angiography and perfusion assessment. The development of target-specific fluorophores and advances in imaging technology will allow real-time intraoperative fluorescence imaging to develop into an essential intraoperative navigation tool. This property may contribute to enhancing both accuracy and safety of minimally invasive surgery.

Keywords: Fluorescence imaging; Indocyanine green; Intraoperative cholangiography; Liver cancer; Pancreatic cancer.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Fluorescence*
Humans
Indocyanine Green
Liver Neoplasms / diagnostic imaging
Liver Neoplasms / surgery*
Minimally Invasive Surgical Procedures / methods*
Surgery, Computer-Assisted / methods*

Substances

Indocyanine Green