Regulatory T Cells and Profile of FOXP3 Isoforms Expression in Peripheral Blood of Patients with Myelodysplastic Syndromes

Galina A Dudina; Almira D Donetskova; Marina M Litvina; Alexander N Mitin; Tatiana A Mitina; Sergey A Polyakov

doi:10.1155/2018/8487403

Regulatory T Cells and Profile of FOXP3 Isoforms Expression in Peripheral Blood of Patients with Myelodysplastic Syndromes

Adv Hematol. 2018 Oct 10:2018:8487403. doi: 10.1155/2018/8487403. eCollection 2018.

Authors

Galina A Dudina¹, Almira D Donetskova^{2

3}, Marina M Litvina², Alexander N Mitin², Tatiana A Mitina⁴, Sergey A Polyakov⁵

Affiliations

¹ Loginov Moscow Clinical Center of the Moscow Health Department, 111123 Moscow, Russia.
² National Research Center-Institute of Immunology Federal Medical-Biological Agency of Russia, 115522 Moscow, Russia.
³ Pirogov Russian National Research Medical University, 117997 Moscow, Russia.
⁴ Moscow Regional Research Clinical Institute Named after MF Vladimirsky, 129110 Moscow, Russia.
⁵ Celgene International Holdings Corporation, 125047 Moscow, Russia.

Abstract

We have investigated the frequencies of regulatory T cells and the level of FOXP3 isoforms expression in peripheral blood of patients with myelodysplastic syndromes and found the significant reduction of regulatory T cells at all stages of the disease. At the same time in untreated patients, we observed the shift in the FOXP3 isoforms expression profile towards the full-length molecule possibly due to inflammation. Based on the already known information about the potentially higher functional activity of FOXP3 molecule lacking exon 2, we have also hypothesized that our finding may explain the high risk of autoimmune disorders in this disease.