Abstract
FAS can be mutated in individuals diagnosed with unicentric and idiopathic multicentric Castleman disease.
Defective lymphocyte apoptosis may be a pathological mechanism shared between Castleman disease and autoimmune lymphoproliferative syndrome.
Publication types
-
Case Reports
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adult
-
Amino Acid Sequence
-
Animals
-
Castleman Disease / diagnosis*
-
Cell Line
-
Cell Membrane / metabolism
-
Fas Ligand Protein / metabolism
-
Humans
-
Male
-
Pedigree
-
Polymorphism, Single Nucleotide
-
Protein Binding
-
Sequence Alignment
-
fas Receptor / genetics
-
fas Receptor / metabolism*
Substances
-
FAS protein, human
-
Fas Ligand Protein
-
fas Receptor
Supplementary concepts
-
Multi-centric Castleman's Disease