When Soluble Fibers Meet Hepatocellular Carcinoma: The Dark Side of Fermentation

Suchira Gallage; Elena Kotsiliti; Mathias Heikenwalder

doi:10.1016/j.cmet.2018.10.009

When Soluble Fibers Meet Hepatocellular Carcinoma: The Dark Side of Fermentation

Cell Metab. 2018 Nov 6;28(5):673-675. doi: 10.1016/j.cmet.2018.10.009.

Authors

Suchira Gallage¹, Elena Kotsiliti¹, Mathias Heikenwalder²

Affiliations

¹ Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 242, 69120 Heidelberg, Germany.
² Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 242, 69120 Heidelberg, Germany; Institute of Molecular Immunology and Experimental Oncology, Technical University of Munich, 81675 Munich, Germany. Electronic address: m.heikenwaelder@dkfz.de.

PMID: 30403986
DOI: 10.1016/j.cmet.2018.10.009

Abstract

Fermentation of dietary soluble fibers by our gut microbiota generates short-chain fatty acids (SCFAs) and metabolites, upholding health and being a valuable food supplement. Recently, in Cell, Singh et al. (2018) discovered that fermentable, dietary soluble fibers (e.g., inulin) induced cholestasis and hepatocellular carcinoma (HCC) while improving metabolic dysfunction.

Publication types

Comment

MeSH terms

Adult
Carcinoma, Hepatocellular*
Cholestasis
Dietary Fiber
Fatty Acids, Volatile
Fermentation*
Humans
Liver Neoplasms

Substances

Dietary Fiber
Fatty Acids, Volatile