12 β-Acetyloxyperforatin, a New Limonoid from Harrisonia Perforata

Nat Prod Res. 2019 Oct;33(19):2830-2836. doi: 10.1080/14786419.2018.1508139. Epub 2018 Nov 3.

Abstract

A new A, D-seco limonoid, named 12-acetyloxyperforatin (1), along with three known ones, were isolated from the leaves of Harrisonia perforata. Their structures were elucidated on the basis of spectroscopic analysis, including extensive NMR techniques and computational modelling. These compounds showed no inhibitory activity against the 11β-HSD1 enzyme.

Keywords: 12β-Acetyloxyperforatin; Harrisonia perforata; computational modelling; limonoid.

Publication types

  • Video-Audio Media

MeSH terms

  • 11-beta-Hydroxysteroid Dehydrogenase Type 1 / antagonists & inhibitors
  • 11-beta-Hydroxysteroid Dehydrogenase Type 1 / genetics
  • 11-beta-Hydroxysteroid Dehydrogenase Type 1 / metabolism
  • 11-beta-Hydroxysteroid Dehydrogenase Type 2 / antagonists & inhibitors
  • 11-beta-Hydroxysteroid Dehydrogenase Type 2 / metabolism
  • Animals
  • Drug Evaluation, Preclinical
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology*
  • Humans
  • Limonins / chemistry*
  • Limonins / pharmacology
  • Magnetic Resonance Spectroscopy
  • Mice
  • Models, Molecular
  • Molecular Structure
  • Plant Leaves / chemistry
  • Simaroubaceae / chemistry*

Substances

  • Enzyme Inhibitors
  • Limonins
  • 11-beta-Hydroxysteroid Dehydrogenase Type 1
  • 11-beta-Hydroxysteroid Dehydrogenase Type 2
  • HSD11B1 protein, human
  • HSD11B2 protein, human