To assess levels of Interleukin-1 β and CRP, in Diabetic and Non-diabetic Myocardial Infarction patients, prior to and post angioplasty. 200 patients were recruited in the study. MI patients between the age of 40 and 60 years. Patients came to NICVD with complaints of chest pain, positive Troponin T test and ECG was the confirmatory test for MI. They were divided into 2 groups 100 patients each. First group comprised of MI patients without DMT-II and second group comprised of MI patients with DMT-II. Serum triglycerides, cholesterol, LDL and HDL, FBS, by enzymatic kits, Insulin by RIA. HbA1C, Interleukin-1 β and CRP by ELIZA. Interleukin1β and CRP were significantly higher (P<0.001) in patients at the time of the infarction, prior to angioplasty as compared post angioplasty levels in both groups, which indicate their importance in development of ischemia and MI. FBS and Insulin were significantly higher (P<0.001), while HDL and HbA1C were significantly lower (P<0.001) in MI without DMT-II when compared to MI with DMT-II. BMI, SBP pressure were significantly higher (P<0.001) in MI patients with DMT-II when compared with MI patients without DMT-II. Interleukin1β and CRP were found to be significantly higher prior to angioplasty as compared to post angioplasty levels in both groups which confirms their role in development of ischemia and MI.