Objective: To explore the association between dietary supplementation during pregnancy and low birth weight. Methods: 11 311 pregnant women who had regularly visited outpatient gynecology clinic of Wuhan Women and Children Medical Center with intention to delivery in the hospital were recruited in the cohort between September 2012 and October 2014. Social-demographic characteristics of pregnant women and spouses, dietary supplementation during pregnancy, pre-pregnancy body mass index (BMI), exercise in the third trimester, work during pregnancy, pregnancy complications and related pregnancy information were collected through self-designed questionnaires, maternal health manuals and medical records. Birth weight of the newborns was measured. Non-conditional multivariate logistic regression analysis was used to determine the correlation between dietary supplementation and low birth weight. Results: 11 311 pregnant women were (28.21±3.70) years old, and they gave birth to 477 low birth weight newborns (4.2%). Iron supplementation during the whole period of pregnancy (OR (95%CI): 0.60 (0.43-0.63)) and folic acid supplementation during the early pregnancy (OR (95%CI): 0.74 (0.60-0.90)) were negatively associated with low birth weight. Conclusion: Supplementation of iron during the whole period of pregnancy and folic acid during the early pregnancy would reduce the risk of low birth weight.
目的： 探讨孕期服用膳食补充剂与低出生体重的关系。 方法： 以2012年9月至2014年10月在武汉市妇幼保健院定期产检并拟在该院分娩的11 311名孕妇为研究对象，通过自制调查问卷、孕产妇保健手册和病历收集孕妇及丈夫的社会人口学特征、孕期膳食补充剂服用情况、孕前BMI、孕晚期锻炼情况、孕期工作情况、妊娠合并症及相关妊娠期信息等资料，并测量新生儿出生体重。采用非条件多因素logistic回归模型分析孕期服用膳食补充剂与低出生体重的关系。 结果： 11 311名孕妇年龄为（28.2±3.7）岁，新生儿低出生体重发生率为4.2%（477例）。整个孕期服用铁剂[OR（95%CI）：0.60（0.43~0.83）]和孕早期补充叶酸[OR（95%CI）：0.74（0.60~0.90）]是低出生体重的负相关因素。 结论： 整个孕期补充铁剂和孕早期补充叶酸可降低新生儿低出生体重风险。.
Keywords: Birth weight; Dietary supplements; Pregnant women; Prospective studies.