Characterization of a multidrug resistant Citrobacter amalonaticus clinical isolate harboring blaNDM-1 and mcr-1.5 genes

Infect Genet Evol. 2019 Jan:67:51-54. doi: 10.1016/j.meegid.2018.10.020. Epub 2018 Oct 31.

Abstract

A multidrug resistant isolate, identified as Citrobacter amalonaticus using MALDI-TOF MS and confirmed by genomic analysis, was recovered from a pediatric patient in a hospital from Buenos Aires, Argentina. By whole-genome sequencing a total of 16 resistance genes were detected, including blaNDM-1 and mcr-1.5. To the best of our knowledge this is the first description of these two genes together in a clinical isolate of the Citrobacter genus.

Keywords: Carbapenem; Citrobacter amalonaticus; Colistin; Mcr-1; blaNDM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Carbapenems / pharmacology
  • Citrobacter / classification
  • Citrobacter / drug effects*
  • Citrobacter / genetics*
  • Citrobacter / isolation & purification
  • Colistin / pharmacology
  • Drug Resistance, Multiple, Bacterial*
  • Enterobacteriaceae Infections / microbiology*
  • Humans
  • Microbial Sensitivity Tests
  • Phylogeny
  • beta-Lactamases / genetics*

Substances

  • Anti-Bacterial Agents
  • Carbapenems
  • beta-Lactamases
  • beta-lactamase NDM-1
  • Colistin