The Helix Twist: Damage and Repair Follows the DNA Minor Groove

Eran Kotler; Eran Segal

doi:10.1016/j.cell.2018.10.034

The Helix Twist: Damage and Repair Follows the DNA Minor Groove

Cell. 2018 Nov 1;175(4):902-904. doi: 10.1016/j.cell.2018.10.034.

Authors

Eran Kotler¹, Eran Segal²

Affiliations

¹ Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot 7610001, Israel; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel. Electronic address: eran.kotler@weizmann.ac.il.
² Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot 7610001, Israel; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel. Electronic address: eran.segal@weizmann.ac.il.

PMID: 30388449
DOI: 10.1016/j.cell.2018.10.034

Abstract

Mutation frequencies vary along the genome, but the factors determining this variability are only partially understood. Pich et al. unravel a ∼10 bp periodicity in mutation rates at nucleosome-proximal regions that follows minor groove orientation. Opposing differential DNA damage and repair processes could shape genetic divergence irrespective of selection.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

DNA
Genome
Germ-Line Mutation*
Nucleic Acid Conformation
Nucleosomes*

Substances

Nucleosomes
DNA